Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남태규 | - |
dc.date.accessioned | 2021-07-27T02:15:46Z | - |
dc.date.available | 2021-07-27T02:15:46Z | - |
dc.date.issued | 2020-01 | - |
dc.identifier.citation | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, v. 35, Issue. 1, Page. 1-20 | en_US |
dc.identifier.issn | 1475-6366 | - |
dc.identifier.uri | https://www.proquest.com/docview/2463571191/fulltextPDF/8296970D68824359PQ/1?accountid=11283 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/163274 | - |
dc.description.abstract | Inflammatory bowel disease (IBD) is a chronic immuno-inflammation in gastrointestinal tract. We have evaluated the activity of the compounds to inhibit the adhesion of monocytes to colon epithelial cells is triggered by a pro-inflammatory cytokine, tumour necrosis factor (TNF)-?. The in vitro activity of the compounds, 13b (an ureido-derivative), 14c, 14j, 14k, 14n (thioureido-), 18c and 18d (sulfonamido-), was in correlation with in vivo anti-colitis activity revealed as significant recovery in body- and colon-weights and colon myeloperoxidase level, a biochemical marker of inflammation reflecting neutrophil infiltration. In vivo, TNBS-induced changes in the expression of inflammatory cytokines (TNF-?, IL-6, IL-1?, IL-10, and TGF-?), NLRP3 inflammasome components (NLRP-3, Caspase-1, and IL-18), and epithelial junction molecules (E-cadherin, claudin2/3, and ZO-1) were blocked and recovered by oral administration of the compounds (1?mg/kg). Compound 14n which showed the best efficacy can be a promising lead for orally available therapeutics for pathology of IBD. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | TAYLOR & FRANCIS LTD | en_US |
dc.title | Synthesis, activity and mechanism of alkoxy-, carbamato-, sulfonamido-, thioureido-, and ureido-derivatives of 2,4,5-trimethylpyridin-3-ol against inflammatory bowel disease | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 35 | - |
dc.identifier.doi | 10.1080/14756366.2019.1677637 | - |
dc.relation.page | 1-20 | - |
dc.relation.journal | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
dc.contributor.googleauthor | Chaudhary, Chhabi Lal | - |
dc.contributor.googleauthor | Gurung, Pallavi | - |
dc.contributor.googleauthor | Jang, Seoul | - |
dc.contributor.googleauthor | Banskota, Suhrid | - |
dc.contributor.googleauthor | Nam, Tae-Gyu | - |
dc.contributor.googleauthor | Kim, Jung-Ae | - |
dc.contributor.googleauthor | Jeong, Byeong-Seon | - |
dc.relation.code | 2020054054 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | tnam | - |
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