A Structural Study on Antisence Dimers, Modified Adenosine-Thymidine Phosphorothioate
- Title
- A Structural Study on Antisence Dimers, Modified Adenosine-Thymidine Phosphorothioate
- Author
- 이철훈
- Keywords
- Antisense; NMR; dimer; nucleotide
- Issue Date
- 2000-12
- Publisher
- The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
- Citation
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v. 10, no. 6, page. 889-892
- Abstract
- Antisense molecules are structurally simple linear oligomers of nucleotides. They can recognize a complementary sequence by base pairing, therefore, antisense drugs composed of 15-16 bases are potentially useful, unlike drugs such as protein agonists, antagonists, and inhibitors. Since antisense oligomers are classified as nucleotides, they are subject to attack by nucleases. In order to be antisense drugs resistant to degradation by nucleases, the structural modifications in the linkages, bases, and sugars to satisfy this requirement are considerable. We attempted in this study, to synthesize 16-mer antisenses with a modified linkage and adenosine. When studying on the three-dimensional structure of the oligomer, however, the existence of isomers may complicate the interpretation of the NMR data. Therefore, an attempt was made to eliminate the above problem, thus, two dimers were synthesized and their structural studies were carried out.
- URI
- https://www.koreascience.or.kr/article/JAKO200011920816425.pagehttps://repository.hanyang.ac.kr/handle/20.500.11754/162225
- ISSN
- 1017-7825; 1738-8872
- Appears in Collections:
- COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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