Two inv dup(15) chromosomes in a woman with repeated abortions
- Title
- Two inv dup(15) chromosomes in a woman with repeated abortions
- Author
- 이철훈
- Keywords
- inv dup(15); repeated abor-tions
- Issue Date
- 2001-12
- Publisher
- WILEY-LISS
- Citation
- AMERICAN JOURNAL OF MEDICAL GENETICS, v. 104, issue. 4, page. 303-306
- Abstract
- A 40-year-old, phenotypically normal woman,with a history of two repeated abortions andno child, had two additional, small, bisatel-lited, and apparently metacentric chromo-somes. Various banding and microsatelliteanalyses indicated that the additional chromo-somes were inv dup(15)(q11q11) without thePrader-Willi/Angelman syndromes critical re-gion, and therefore without phenotypic effects.Her father had a single, identical additionalinv dup(15) chromosome. Her husband waschromosomally normal, but sperm analysisindicated a reduced motility and a reducedfrequency of morphologically normal sperm.In view of these ®ndings, it was deduced thatthe inv dup(15) chromosome in the father wastransmitted in duplicate to the woman. Indi-viduals with two additional inv dup(15) chro-mosomes in the literature were reviewed, andpossible correlation of the two additional invdup(15) chromosomes in the woman and herrepeated abortions was discussed.
- URI
- https://onlinelibrary.wiley.com/doi/full/10.1002/ajmg.10082https://repository.hanyang.ac.kr/handle/20.500.11754/160465
- ISSN
- 0148-7299
- DOI
- 10.1002/ajmg.10082
- Appears in Collections:
- COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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