Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 원정임 | - |
dc.date.accessioned | 2021-03-09T01:02:21Z | - |
dc.date.available | 2021-03-09T01:02:21Z | - |
dc.date.issued | 2019-06 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF DATA MINING AND BIOINFORMATICS, v. 22, no. 3, page. 216-230 | en_US |
dc.identifier.issn | 1748-5673 | - |
dc.identifier.issn | 1748-5681 | - |
dc.identifier.uri | http://www.inderscience.com/offer.php?id=100623 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/160277 | - |
dc.description.abstract | The advent of high-throughput Next-Generation Sequencing (NGS) technology has brought in a new genomics era. It is widely utilised not only for genomic but also for transcriptome sequencing. NGS-based transcriptomic methods, including RNA-seq, are widely used to study gene expression regulation. Recently, post-transcriptional gene regulation has been studied by several RNA degradome sequencing methods that differ from RNA-seq and directly profile degraded RNAs. Parallel Analysis of RNA Ends (PARE) sequencing is one of these methods. It is widely used for identifying microRNA targets and nonsense-mediated mRNA decay events as well as for global analysis of RNA degradation. We have developed WebPORD, a user-friendly web-based pipeline for analysing the PARE sequencing data. This pipeline trims and applies several filters to PARE sequencing. In addition, this pipeline provides a degradome table and degradome-plots for users to further analyse RNA degradation at a genomic scale. This is the first web-based pipeline for global analysis of RNA degradation using PARE data from animals and plants, which provides mechanistic insights into post-transcriptional gene regulation. | en_US |
dc.description.sponsorship | This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. 2017R1D1A1B03030969 to J-I. W.) and by the National Research Foundation of Korea (NRF) grants funded by the Korea government (NRF-2017R1A2B4007831 to J.H. Y and NRF-2018R1D1A1B07049751 to D-H. J). This work was also supported by a grant from the Next-Generation BioGreen 21 Program (Project No. PJ01366801), Rural Development Administration, Republic of Korea to D-H. J. and by a grant from Hallym University (HRF-201409-001) to D-H. J. | en_US |
dc.language.iso | en | en_US |
dc.publisher | INDERSCIENCE ENTERPRISES LTD | en_US |
dc.subject | web-based pipeline | en_US |
dc.subject | next-generation sequencing | en_US |
dc.subject | RNA degradome | en_US |
dc.subject | parallel analysis of RNA ends | en_US |
dc.title | WebPORD: a web-based pipeline of RNA degradome | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1504/IJDMB.2019.100623 | - |
dc.relation.journal | INTERNATIONAL JOURNAL OF DATA MINING AND BIOINFORMATICS | - |
dc.contributor.googleauthor | Won, Jung-Im | - |
dc.contributor.googleauthor | Lee, JunBeom | - |
dc.contributor.googleauthor | Lee, HeonWoo | - |
dc.contributor.googleauthor | Shin, JaeMoon | - |
dc.contributor.googleauthor | Yoon, JeeHee | - |
dc.contributor.googleauthor | Jeong, Dong-Hoon | - |
dc.relation.code | 2019039811 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | CENTER FOR INNOVATION IN ENGINEERING EDUCATION | - |
dc.identifier.pid | jiwon | - |
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