The Role of Lozenge in Drosophila Hematopoiesis
- Title
- The Role of Lozenge in Drosophila Hematopoiesis
- Author
- 심지원
- Keywords
- crystal cells; Drosophila melanogaster; hematopoiesis; lozenge; lymph gland; melanization; prophenoloxidase; RUNX
- Issue Date
- 2020-02
- Publisher
- KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
- Citation
- MOLECULES AND CELLS, v. 43, no. 2, page. 114-120
- Abstract
- Drosophila hematopoiesis is comparable to mammalian differentiation of myeloid lineages, and therefore, has been a useful model organism in illustrating the molecular and genetic basis for hematopoiesis. Multiple novel regulators and signals have been uncovered using the tools of Drosophila genetics. A Runt domain protein, lozenge, is one of the first players recognized and closely studied in the hematopoietic lineage specification. Here, we explore the role of lozenge in determination of prohemocytes into a special class of hemocyte, namely the crystal cell, and discuss molecules and signals controlling the lozenge function and its implication in immunity and stress response. Given the highly conserved nature of Runt domain in both invertebrates and vertebrates, studies in Drosophila will enlighten our perspectives on Runx-mediated development and pathologies.
- URI
- http://www.molcells.org/journal/view.html?doi=10.14348/molcells.2019.0249&https://repository.hanyang.ac.kr/handle/20.500.11754/158878
- ISSN
- 1016-8478; 0219-1032
- DOI
- 10.14348/molcells.2019.0249
- Appears in Collections:
- COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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