알코올 의존과 세로토닌 수송체 유전자 다형성의 연관
- Title
- 알코올 의존과 세로토닌 수송체 유전자 다형성의 연관
- Other Titles
- Association of Serotonin Transporter Gene Polymorphism with Alcohol Dependence
- Author
- 채영규
- Keywords
- Serotonin transporter; Polymorphism; 5-HTTLPR; Alcohol dependence
- Issue Date
- 2003-11
- Publisher
- 대한생물정신의학회
- Citation
- 생물정신의학, v. 10, no. 2, page. 159-167
- Abstract
- Objective:Under the hypothesis that 5-HTTLPR polymorphism plays some role in the susceptibility or vulnerability of some subgroup of alcohol dependence, associations of 5-HTTLPR polymorphism with alcohol dependence were examined.
Method:This association analysis included 109 Korean alcohol dependent and 113 Korean control subjects. DNA of all subjects were genotyped for the biallelic functional polymorphism in the 5-HTTLPR. Considering the likelihood of heterogeneity in the alcohol dependence phenotype, alcohol dependent subjects were subgrouped by onset age, family history of alcohol dependence and severity of withdrawal symptoms.
Results:There were no significant differences in the frequencies of either the 5-HTTLPR genotype or the short vs. long allele in alcohol dependent and control subjects. The frequency of the S allele and S-carrier (LS or SS genotype) was significantly increased in the early onset alcohol dependent subjects and the familial alcohol dependent subjects compared with that in the control subjects.
Conclusion:The results suggest that the 5-HTT 'S' promoter polymorphism is associated with an increased susceptibility or vulnerability to develop early onset alcohol dependence and familial alcohol dependence, which characterize Cloninger's type 2 alcohol dependence.
- URI
- http://journal.biolpsychiatry.or.kr/asp/journal_abstrackt.asp?no=0092003016&m=0https://repository.hanyang.ac.kr/handle/20.500.11754/156538
- ISSN
- 2005-7571
- Appears in Collections:
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > MOLECULAR AND LIFE SCIENCE(분자생명과학과) > Articles
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