Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김효준 | - |
dc.date.accessioned | 2020-10-26T02:16:15Z | - |
dc.date.available | 2020-10-26T02:16:15Z | - |
dc.date.issued | 2004-12 | - |
dc.identifier.citation | BULLETIN OF THE KOREAN CHEMICAL SOCIETY(대한화학회), v.25, No.12, Page.1845-1849 | en_US |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.uri | https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART000942293 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/154803 | - |
dc.description.abstract | Apolipoprotein B-100 (Apo-B100) is a major protein component for low density lipoproteins (LDL). A number of mimetic peptides of Apo-B100 were screened from the phase-displayed random peptide library by utilizing monoclonal antibody (B9). Mimetic peptide for B9 epitope against apo B-100 was CRNVPPIFNDVYWIAF (pB1). From the BLAST search, the mimetic peptide pB1 had 40% homology with apo B-100. As a result of the structural determination of this mimotope using homo/hetero nuclear 2D-NMR techniques and NMR-based distance geometry (DG)/molecular dynamic (MD) computations, DG structure had low penalty value of 0.3-0.6 Å2 and the total RMSD was 0.5-1.5 Å. Moreover, pB1 structure included a weak 310-helix from Ile7 to Trp13. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | KOREAN CHEMICAL SOC(대한화학회) | en_US |
dc.subject | Apolipoprotein B-100 | en_US |
dc.subject | NMR spectroscopy | en_US |
dc.subject | Molecular dynamic computation | en_US |
dc.title | Solution state structure of pB1, the mim otopic peptide of apolipoprotein B-100, by NMR | en_US |
dc.type | Article | en_US |
dc.relation.journal | BULLETIN OF THE KOREAN CHEMICAL SOCIETY(대한화학회) | - |
dc.contributor.googleauthor | Lee, Sungran | - |
dc.contributor.googleauthor | Kim, Daesung | - |
dc.contributor.googleauthor | Kim, Hyojoon | - |
dc.contributor.googleauthor | Lee, Yongwoo | - |
dc.contributor.googleauthor | Won, Hoshik | - |
dc.relation.code | 2012201551 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E] | - |
dc.sector.department | DEPARTMENT OF MOLECULAR AND LIFE SCIENCE | - |
dc.identifier.pid | kimhj104 | - |
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