목초액의 혈소판 응집억제를 통한 혈행개선 작용에 관한 연구
- Title
- 목초액의 혈소판 응집억제를 통한 혈행개선 작용에 관한 연구
- Other Titles
- Improvement of Haemostasis Mediated by Anti-Platelet Activities by Plant Vinegar
- Author
- 배옥남
- Keywords
- Plant vinegar; Platelets; Cytotoxicity; Antiplatelet activity; Cardiovascular disease
- Issue Date
- 2004-03
- Publisher
- 한국독성학회
- Citation
- Journal of Toxicology and Public Health, v. 20, No. 1, Page. 137-142
- Abstract
- We investigated the effects of plant vinegar on platelets and blood coagulation system. Plant vinegar inhibited in vitro platelet aggregation in a concentration dependent manner, when platelets were activated by thrombin and collagen. In addition, plant vinegar showed inhibitory effects on the serotonin secretion induced by thrombin in a concentration dependent manner. However, treatment
with plant vinegar to platelets did not induce any cytotoxicity, as determined by the release of lactate dehydrogenase. Plant vinegar did not change the coagulation parameters such as activated partial thromboplastin time (aPTT) and prothrombin time (PT) using rat citrated plasma. In vivo study revealed that, treatment with plant vinegar prolonged the bleeding time from mouse tail. All these
results suggest that plant vinegar might improve blood hemostasis mediated via antiplatelet activities.
- URI
- http://www.dbpia.co.kr/journal/articleDetail?nodeId=NODE00544171&language=ko_KRhttps://repository.hanyang.ac.kr/handle/20.500.11754/136800
- ISSN
- 1976-8257; 2234-2753
- Appears in Collections:
- COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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