금속산화물 나노입자의 물리화학적 특성과 생물학적 반응과의 상관관계 연구

Abstract

1) bioaccumulation of TiO2 NPs with different hydrodynamic size distributions, where agglomeration of TiO2 NPs over 280 nm showed strong influence on the bioaccumulation TiO2 NPs, and 2) bioaccumulation and toxicity of ZnO NPs with different surface charges, where the bioaccumulation of ZnO NP was found strongly dependent on their surface charge but their toxicity was mainly correlated with Zn ion released from ZnO NPs.; Compared to their bulk counterpart, nanometer-sized materials are often found to have very unique physicochemical properties, which also reported to cause distinct biological toxicities. Consequently, it is necessary to assess potential risks of all the novel nanoparticles (NPs) and regulate them according to their assessment results. The computational approaches such as QSAR (quantitative structure activity relationship) are considered as promising alternative for the efficient assessment of NPs and screening NPs with higher potential toxicities for further in vitro and in vivo testing. Among the various physicochemical properties of NPs, intrinsic properties of NP are frequently used as alternative dosing metrics of NPs. However, extrinsic physicochemical properties are also reported to have strong influence on the biological toxicities of NPs and should be considered as key factors of alternative dosing metrics for NPs. In this study, by adapting the QSAR approach, we investigated the relationships between the extrinsic physicochemical properties of NPs and their biological uptakes and toxicities. Based on our experimental data, we have developed a model to describe the biological interactions of NPs with D. magna. Particularly, we will present two case studies of QNTR