Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 신인철 | - |
dc.contributor.author | 유승아 | - |
dc.date.accessioned | 2020-02-25T16:32:30Z | - |
dc.date.available | 2020-02-25T16:32:30Z | - |
dc.date.issued | 2015-02 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/129387 | - |
dc.identifier.uri | http://hanyang.dcollection.net/common/orgView/200000426642 | en_US |
dc.description.abstract | Creatine kinase B (CKB) is a cytosolic isoform of creatine kinase that regulates energy homeostasis at high level of energy demanded sites. To identify the effect of CKB in breast cancer cells, I overexpressed CKB to CKB low MDA-MB-231 cells. The overexpression of CKB resulted in increase resistance to drug treatment, UV radiation and energy stresses. Transforming growth factor beta (TGF-β) has tumor-suppressive effects such as differentiation, apoptosis in normal cells. However, it is causally related with cancer progression in malignant cancer cells. When the effect of CKB on TGF-β signaling was examined, the cells were treated with TGF-β treatment increased the basal phosphorylation level of Smad2, an indicator of TGF-β signaling activation, was up-regulated in MDA-MB-231 CKB cells compared to MDA-MB-231 vec cells. I also identified that TGF-β considerably enhanced cell viability and decreased doxorubicin-induced apoptosis during doxorubicin treatment in MDA-MB-231 CKB cells. These results suggest that CKB overexpression attenuates various stress-induced apoptosis and potentiates their resistant ability by enhancement of TGF-β signaling in MDA-MB-231 cells. | - |
dc.publisher | 한양대학교 | - |
dc.title | 크레아틴 인산화효소 B 에 의한 TGF-β 신호전달 조절 | - |
dc.title.alternative | Modulation of TGF-beta signaling by creatine kinase B in breast cancer cells | - |
dc.type | Theses | - |
dc.contributor.googleauthor | 유승아 | - |
dc.contributor.alternativeauthor | Yoo, Seung-ah | - |
dc.sector.campus | S | - |
dc.sector.daehak | 대학원 | - |
dc.sector.department | 생명과학과 | - |
dc.description.degree | Master | - |
dc.contributor.affiliation | 분자세포생물학 | - |
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