Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 류종석 | - |
dc.date.accessioned | 2020-01-21T07:18:46Z | - |
dc.date.available | 2020-01-21T07:18:46Z | - |
dc.date.issued | 2019-11 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, No. 23, Article no. 5850 | en_US |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://www.mdpi.com/1422-0067/20/23/5850 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/122153 | - |
dc.description.abstract | Self-assembling peptides are biomedical materials with unique structures that are formed in response to various environmental conditions. Governed by their physicochemical characteristics, the peptides can form a variety of structures with greater reactivity than conventional non-biological materials. The structural divergence of self-assembling peptides allows for various functional possibilities; when assembled, they can be used as scaffolds for cell and tissue regeneration, and vehicles for drug delivery, conferring controlled release, stability, and targeting, and avoiding side effects of drugs. These peptides can also be used as drugs themselves. In this review, we describe the basic structure and characteristics of self-assembling peptides and the various factors that affect the formation of peptide-based structures. We also summarize the applications of self-assembling peptides in the treatment of various diseases, including cancer. Furthermore, the in-cell self-assembly of peptides, termed reverse self-assembly, is discussed as a novel paradigm for self-assembling peptide-based nanovehicles and nanomedicines. | en_US |
dc.description.sponsorship | This research was funded by the Korea Health Technology R&D Project grant number HI16C1085 through the Korea Health Industry Development Institute. And The APC was funded by Korea Health Technology R&D Project grant number HI16C1085. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | MDPI | en_US |
dc.subject | peptide | en_US |
dc.subject | self-assembly | en_US |
dc.subject | nanostructure | en_US |
dc.subject | drug delivery | en_US |
dc.subject | disease | en_US |
dc.title | Self-Assembling Peptides and Their Application in the Treatment of Diseases | en_US |
dc.type | Article | en_US |
dc.relation.no | 5850 | - |
dc.relation.volume | 20 | - |
dc.identifier.doi | 10.3390/ijms20235850 | - |
dc.relation.page | 1-22 | - |
dc.relation.journal | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.contributor.googleauthor | Lee, Sungeun | - |
dc.contributor.googleauthor | Trinh, Trang H.T. | - |
dc.contributor.googleauthor | Yoo, Miryeong | - |
dc.contributor.googleauthor | Shin, Junwu | - |
dc.contributor.googleauthor | Lee, Hakmin | - |
dc.contributor.googleauthor | Kim, Jaehyeon | - |
dc.contributor.googleauthor | Hwang, Euimin | - |
dc.contributor.googleauthor | Lim, Yong-beom | - |
dc.contributor.googleauthor | Ryou, Chongsuk | - |
dc.relation.code | 2019041550 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | cryou2 | - |
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