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Anti-Angiogenic Effect of Asperchalasine A Via Attenuation of VEGF Signaling

Title
Anti-Angiogenic Effect of Asperchalasine A Via Attenuation of VEGF Signaling
Author
유혜현
Keywords
angiogenesis; metastasis; HUVEC; asperchalasine A; VEGF
Issue Date
2019-08
Publisher
MDPI
Citation
BIOMOLECULES, v. 9, No. 8, Article no. 358
Abstract
Cytochalasans are a group of structurally diverse fungal polyketide-amino acid hybrid metabolites that exhibit diverse biological functions. Asperchalasine A was identified and isolated from an extract of the marine-derived fungus, Aspergillus. Asperchalasine A is a cytochalasan dimer which consists of two cytochalasan molecules connected by an epicoccine. This study investigated the potential antiangiogenic effects of Aspergillus extract and asperchalasine A, which significantly inhibited cell adhesion and tube formation in human umbilical vein endothelial cells (HUVECs). Aspergillus extract and asperchalasine A decreased the vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR)-2 mRNA expression in a concentration-dependent manner. In addition, Aspergillus extract and asperchalasine A inhibited angiogenesis via downregulation of VEGF, p-p38, p-extracellular signal-regulated protein kinase (ERK), p-VEGFR-2, and p-Akt signaling pathways. Moreover, Aspergillus extract and asperchalasine A significantly inhibited the amount of blood vessel formation in fertilized chicken eggs using a chorioallantoic membrane assay. Our results provide experimental evidence of this novel biological activity of the potential antiangiogenic substances, Aspergillus extract, and asperchalasine A. This study also suggests that Aspergillus extract and its active component asperchalasine A are excellent candidates as adjuvant therapeutic substances for cancer prevention and treatment.
URI
https://www.mdpi.com/2218-273X/9/8/358http://repository.hanyang.ac.kr/handle/20.500.11754/121937
ISSN
2218-273X
DOI
10.3390/biom9080358
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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