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Pharmacokinetic Properties of Acetyl Tributyl Citrate, a Pharmaceutical Excipient

Title
Pharmacokinetic Properties of Acetyl Tributyl Citrate, a Pharmaceutical Excipient
Author
유혜현
Keywords
acetyl tributyl citrate; pharmaceutical excipient; pharmacokinetics; metabolic stability; plasma
Issue Date
2018-10
Publisher
MDPI AG
Citation
PHARMACEUTICS, v. 10, No. 4, Article no. 177
Abstract
Acetyl tributyl citrate (ATBC) is an (the Food and Drug Administration) FDA-approved substance for use as a pharmaceutical excipient. It is used in pharmaceutical coating of solid oral dosage forms such as coated tablets or capsules. However, the information of ATBC on its pharmacokinetics is limited. The aim of this study is to investigate the pharmacokinetic properties of ATBC using liquid chromatography-tandem mass spectrometric (LC-MS/MS) analysis. ATBC was rapidly absorbed and eliminated and the bioavailability was 27.4% in rats. The results of metabolic stability tests revealed that metabolic clearance may have accounted for a considerable portion of the total clearance of ATBC. These pharmacokinetic data would be useful in studies investigating the safety and toxicity of ATBC.
URI
https://www.mdpi.com/1999-4923/10/4/177http://repository.hanyang.ac.kr/handle/20.500.11754/121563
ISSN
1999-4923
DOI
10.3390/pharmaceutics10040177
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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