Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유혜현 | - |
dc.date.accessioned | 2020-01-02T05:22:22Z | - |
dc.date.available | 2020-01-02T05:22:22Z | - |
dc.date.issued | 2018-12 | - |
dc.identifier.citation | AMERICAN JOURNAL OF CHINESE MEDICINE, v. 46, No. 8, Page. 1879-1897 | en_US |
dc.identifier.issn | 0192-415X | - |
dc.identifier.issn | 1793-6853 | - |
dc.identifier.uri | https://www.worldscientific.com/doi/abs/10.1142/S0192415X18500945 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/121472 | - |
dc.description.abstract | A variety of products have been developed with red ginseng (RG, the steamed roots of Panax ginseng Meyer). To clarify the immunomodulating effects of water-extracted RG (wRG), 50% ethanol-extracted RG (eRG), enzyme-treated eRG (ERG) and probioticfermented eRG (FRG), we examined their immunopotentiating and immunosuppressive effects in mice with cyclophosphamide (CP)-induced immunosuppression (CI) or 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis (TC). Oral administration of RG in CI mice significantly increased blood IFN-gamma levels. Treatment with RG also increased the tumoricidal effects of CI mouse splenic cytotoxic T (Tc) and NK cells against YAC-1 cells. Treatment with RGs, in particular FRG and wRG, significantly increased Th1 cell differentiation. Treatment with RG except wRG increased Treg cell differentiation. However, wRG alone increased IL-6 and IL-17 expression in the colon of CI mice. Furthermore, RG alleviated colitis in TC mice. FRG most potently suppressed TNBS-induced colon shortening, NF-kappa B activation and TNF-alpha and IL-17 expression and increased IL-10 expression. RGs inhibited TNF-alpha expression and increased IL-10 expression in lipopolysaccharide-stimulated primary macrophages in vitro while the differentiation of splenic T cells into type 1 T (Th1) and regulatory T (Treg) cells was increased by FRG in vitro. In conclusion, FRG can alleviate immunosuppression and inflammation by inhibiting macrophage activation and regulating Thl and Treg cell differentiation. | en_US |
dc.description.sponsorship | This research was also supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT (NRF-2017R1A5A2014768). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | WORLD SCIENTIFIC PUBL CO PTE LTD | en_US |
dc.subject | Immunomodulation | en_US |
dc.subject | Immunosuppression | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Probiotic-Fermented Red Ginseng | en_US |
dc.title | Fermented Red Ginseng Alleviates Cyclophosphamide-Induced Immunosuppression and 2,4,6-Trinitrobenzenesulfonic Acid-Induced Colitis in Mice by Regulating Macrophage Activation and T Cell Differentiation | en_US |
dc.type | Article | en_US |
dc.relation.no | 8 | - |
dc.relation.volume | 46 | - |
dc.identifier.doi | 10.1142/S0192415X18500945 | - |
dc.relation.page | 1879-1897 | - |
dc.relation.journal | AMERICAN JOURNAL OF CHINESE MEDICINE | - |
dc.contributor.googleauthor | Kim, Jeon-Kyung | - |
dc.contributor.googleauthor | Kim, Jae-Young | - |
dc.contributor.googleauthor | Jang, Se-Eun | - |
dc.contributor.googleauthor | Choi, Min-Sun | - |
dc.contributor.googleauthor | Jang, Hyo-Min | - |
dc.contributor.googleauthor | Yoo, Hae-Hyun | - |
dc.contributor.googleauthor | Kim, Dong-Hyun | - |
dc.relation.code | 2018012236 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | yoohh | - |
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