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Ultrasonic Neuromodulation via Astrocytic TRPA1

Title
Ultrasonic Neuromodulation via Astrocytic TRPA1
Author
이성온
Keywords
ultrasound; neuromodulation; TRPA1; Best1; NMDAR; glutamate
Issue Date
2019-10
Publisher
CELL PRESS
Citation
CURRENT BIOLOGY, v. 29, No. 20, Page. 3386-3401
Abstract
Low-intensity, low-frequency ultrasound (LILFU) is the next-generation, non-invasive brain stimulation technology for treating various neurological and psychiatric disorders. However, the underlying cellular and molecular mechanism of LILFU-induced neuromodulation has remained unknown. Here, we report that LILFU-induced neuromodulation is initiated by opening of TRPA1 channels in astrocytes. The Ca2+ entry through TRPA1 causes a release of gliotransmitters including glutamate through Best1 channels in astrocytes. The released glutamate activates NMDA receptors in neighboring neurons to elicit action potential firing. Our results reveal an unprecedented mechanism of LILFU-induced neuromodulation, involving TRPA1 as a unique sensor for LILFU and glutamate-releasing Best1 as a mediator of glia-neuron interaction. These discoveries should prove to be useful for optimization of human brain stimulation and ultrasonogenetic manipulations of TRPA1.
URI
https://www.sciencedirect.com/science/article/pii/S0960982219310371http://repository.hanyang.ac.kr/handle/20.500.11754/121257
ISSN
0960-9822; 1879-0445
DOI
10.1016/j.cub.2019.08.021
Appears in Collections:
COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > ELECTRICAL ENGINEERING(전자공학부) > Articles
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