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Comparison of clinical efficacy between ultra-LABAs and ultra-LAMAs in COPD: a systemic review with meta-analysis of randomized controlled trials

Title
Comparison of clinical efficacy between ultra-LABAs and ultra-LAMAs in COPD: a systemic review with meta-analysis of randomized controlled trials
Author
이현
Keywords
Chronic obstructive pulmonary disease (COPD); ultra-long acting beta(2)-agonist (LABA); ultra-long-acting muscarinic antagonist (LAMA); meta-analysis
Issue Date
2018-12
Publisher
AME PUBL CO
Citation
JOURNAL OF THORACIC DISEASE, v. 10, no. 12, page. 6522-+
Abstract
Background: A single long-acting bronchodilator, ultra-long acting muscarinic antagonist (ultra-LAMA) or ultra-long acting beta(2)-agonist (ultra-LABA) is preferred for the initial treatment of patients with chronic obstructive pulmonary disease (COPD); however, there are few head-to-head comparative studies between the two. Here, a meta-analysis of randomized controlled trials was performed to compare the clinical efficacy between ultra-LABA and ultra-LAMA in patients with moderate-to-severe COPD.Methods: MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were searched (to March 1, 2017) to identify all published randomized controlled trials.Results: Of the 12,906 articles found by searching the databases, we obtained data from 10,591 patients with COPD (LABA, n= 5,058; LAMA, n= 5,533) in seven published studies. Our results showed that COPD exacerbation were significantly lower in patients taking ultra-LAMA than those taking ultra-LABA (odds ratio = 0.857, P=0.0008). However, no significant differences were observed between ultra-LAMA and ultra-LABA patients regarding improvement in trough forced expiratory volume in 1 s, the transitional dyspnea index, or St. George's Respiratory Questionnaire score.Conclusions: This study suggests that COPD exacerbation occurred less often in patients taking an ultra-LAMA than in those taking an ultra-LABA with similar efficacy of lung function and quality of life.
URI
http://jtd.amegroups.com/article/view/25541/19432http://repository.hanyang.ac.kr/handle/20.500.11754/121200
ISSN
2072-1439; 2077-6624
DOI
10.21037/jtd.2018.11.50
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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