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Comparison of efficacy of low-carbohydrate and low-fat diet education programs in non-alcoholic fatty liver disease: A randomized controlled study

Title
Comparison of efficacy of low-carbohydrate and low-fat diet education programs in non-alcoholic fatty liver disease: A randomized controlled study
Author
전대원
Keywords
carbohydrate; fat; non-alcoholic fatty liver disease
Issue Date
2018-12
Publisher
WILEY
Citation
HEPATOLOGY RESEARCH, v. 48, no. 3, page. E22-E29
Abstract
Aim: Composition of macronutrients is important in non-alcoholic fatty liver disease (NAFLD). Diet education programs that mainly emphasize reducing fat consumption have been used for NAFLD patients. We compared the efficacy of conventional low-fat diet education with low-carbohydrate diet education in Korean NAFLD patients.Methods: One hundred and six NAFLD patients were randomly allocated to low-fat diet education or low-carbohydrate education groups for 8weeks. Liver chemistry, liver/spleen ratio, and visceral fat using abdominal tomography were measured.Results: Intrahepatic fat accumulation decreased significantly in the low-carbohydrate group compared to low-fat group (liver/spleen 0.85 vs. 0.92, P<0.05). Normalization of ALT activity at week 8 was 38.5% for the low-carbohydrate and 16.7% for the low-fat group (P=0.016). Not only liver enzyme, but also low density lipoprotein cholesterol and blood pressure levels significantly decreased in the low-carbohydrate group. Total energy intake was also further decreased in the low-carbohydrate group compared to the low-fat group. Although body weight changes were not different between the two groups, the carbohydrate group had a lower total abdominal fat amount.Conclusions: A low-carbohydrate diet program is more realistic and effective in reducing total energy intake and hepatic fat content in Korean NAFLD patients.
URI
https://onlinelibrary.wiley.com/doi/full/10.1111/hepr.12918http://repository.hanyang.ac.kr/handle/20.500.11754/121158
ISSN
1386-6346; 1872-034X
DOI
10.1111/hepr.12918
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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