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DC FieldValueLanguage
dc.contributor.author전대원-
dc.date.accessioned2019-12-10T20:16:35Z-
dc.date.available2019-12-10T20:16:35Z-
dc.date.issued2018-12-
dc.identifier.citationSCIENTIFIC REPORTS, v. 8, Article no. 7759en_US
dc.identifier.issn2045-2322-
dc.identifier.urihttps://www.nature.com/articles/s41598-018-26019-x-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/121156-
dc.description.abstractThis study correlated conventional ultrasonography (US) signs with the magnetic resonance imaging (MRI) proton density fat fraction (PDFF) to evaluate the diagnostic performance of US signs (alone or combined) to predict presence and degree of hepatic steatosis (HS). Overall, 182 subjects met the study inclusion criteria between February 2014 and October 2016. Four US signs were evaluated independently by two radiologists. MRI PDFF was defined as the average of 24 non-overlapping regions of interest (ROIs) within eight liver segments obtained by drawing three ROIs within each segment. The latter acted as the reference standard to evaluate diagnostic accuracy of the US signs and their combinations. Diagnostic performance of US for HS was assessed using receiver operating characteristic (ROC) curve analyses. There was a strongly positive correlation between some combinations of US signs and PDFF (sigma = 0.780, p < 0.001). The sensitivity, specificity, PPV, and NPV were 96.6%, 74.8%, 64.8%, and 97.9%, respectively, determined using abnormal hepatorenal echoes to detect grade 1 or higher HS (area under the ROC curve = 0.875). The sensitivity and NPV for detecting HS with US were good and US may be considered a suitable screening tool for exclusion of HS.en_US
dc.description.sponsorshipThis study was supported by a research fund from the National Research Foundation of Korea 2011-0007127. The funding source had no role in study design, implementation, data collection, analysis, and interpretation or in the preparation, review, or approval of the manuscript.en_US
dc.language.isoen_USen_US
dc.publisherNATURE PUBLISHING GROUPen_US
dc.subjectLIVER-DISEASEen_US
dc.subjectNONALCOHOLIC STEATOHEPATITISen_US
dc.subjectQUANTITATIVE ULTRASOUNDen_US
dc.subjectDIAGNOSTIC-ACCURACYen_US
dc.subjectQUANTIFICATIONen_US
dc.subjectMETAANALYSISen_US
dc.subjectFIBROSISen_US
dc.subjectBIOPSIESen_US
dc.subjectELASTOGRAPHYen_US
dc.subjectSPECTROSCOPYen_US
dc.titleComparison of conventional sonographic signs and magnetic resonance imaging proton density fat fraction for assessment of hepatic steatosisen_US
dc.typeArticleen_US
dc.relation.volume8-
dc.identifier.doi10.1038/s41598-018-26019-x-
dc.relation.page1-9-
dc.relation.journalSCIENTIFIC REPORTS-
dc.contributor.googleauthorKim, Mimi-
dc.contributor.googleauthorKang, Bo-Kyeong-
dc.contributor.googleauthorJun, Dae Won-
dc.relation.code2018003596-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidnoshin-


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