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Long term outcome of antiviral therapy in patients with hepatitis B associated decompensated cirrhosis

Title
Long term outcome of antiviral therapy in patients with hepatitis B associated decompensated cirrhosis
Author
전대원
Keywords
Hepatitis B; Antiviral agent; Decompensated cirrhosis; Mortality; Hepatocellular carcinoma
Issue Date
2018-12
Publisher
BAISHIDENG PUBLISHING GROUP INC
Citation
WORLD JOURNAL OF GASTROENTEROLOGY, v. 24, no. 40, page. 4606-4614
Abstract
AIMTo investigate survival rate and incidence of hepatocellular carcinoma (HCC) in patients with decompensated cirrhosis in the antiviral era.METHODSWe used the Korean Health Insurance Review and Assessment. Korea's health insurance system is a public single-payer system. The study population consisted of 286871 patients who were prescribed hepatitis B antiviral therapy for the first time between 2007 and 2014 in accordance with the insurance guidelines. Overall, 48365 antiviral treatment-naive patients treated between 2008 and 2009 were included, and each had a follow-up period >= 5 years. Data were analyzed for the 1 st decompensated chronic hepatitis B (CHB) and treatment-naive patients (n = 7166).RESULTSThe mean patient age was 43.5 years. The annual mortality rates were 2.4%-19.1%, and 5-year cumulative mortality rate was 32.6% in 1 st decompensated CHB treatment-naive subjects. But the annual mortality rates sharply decreased to 3.4% (2.4%-4.9%, 2-5 year) after one year of antiviral treatment. Incidence of HCC at first year was 14.3%, the annual incidence of HCC decreased to 2.5% (1.8%-3.7%, 2-5 year) after one year. 5-year cumulative incidence of HCC was 24.1%. Recurrence rate of decompensated event was 46.9% at first year, but the annual incidence of second decompensation events in decompensated CHB treatment-naive patients was 3.4% (2.1%-5.4%, 2-5 year) after one year antiviral treatment. 5-year cumulative recurrence rate of decompensated events was 60.6%. Meanwhile, 5-year cumulative mortality rate was 3.1%, and 5-year cumulative incidence of HCC was 11.5% in compensated CHB treatment-naive patients.CONCLUSIONLong term outcome of decompensated cirrhosis treated with antiviral agent improved much, and incidence of hepatocellular carcinoma and mortality sharply decreased after one year treatment.
URI
https://www.wjgnet.com/1007-9327/full/v24/i40/4606.htmhttp://repository.hanyang.ac.kr/handle/20.500.11754/121154
ISSN
1007-9327; 2219-2840
DOI
10.3748/wjg.v24.i40.4606
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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