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Presence of Sarcopenia and Its Rate of Change Are Independently Associated with Long-term Mortality in Patients with Liver Cirrhosis

Title
Presence of Sarcopenia and Its Rate of Change Are Independently Associated with Long-term Mortality in Patients with Liver Cirrhosis
Author
전대원
Keywords
Liver Cirrhosis; Sarcopenia; Nutrition; Mortality; Prognosis
Issue Date
2018-12
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v. 33, no. 50, Article no. UNSP e299
Abstract
Background: Sarcopenia is associated with a poor prognosis in patients with liver cirrhosis. However, it is not known whether the rate of skeletal muscle depletion is also associated with a poor prognosis. We investigated the prognostic impact of the rate of skeletal muscle depletion in patients with liver cirrhosis.Methods: We included retrospectively all patients with liver cirrhosis who underwent both multiple computed tomography scans and hepatic venous pressure gradient (HVPG) measurements.Results: A total of 131 patients with liver cirrhosis were enrolled. The mean age of the patients was 53.7 years and alcoholic liver disease was the most common cause (61.8%). Sixty-four patients (48.9%) were diagnosed with sarcopenia. The median changes in skeletal muscle area per year (Delta SMA/y) were -0.89%. During a median follow-up period of 46.2 months (range, 3.4-87.6), 45 patients (34.4%) died. In multivariate analyses, age, Child-Pugh score, HVPG, presence of sarcopenia and Delta SMA/y were independently associated with mortality. Cumulative mortality was significantly higher in patients with Delta SMA/y < -2.4% than those with Delta SMA/y >= -2.4% (log-rank test, P < 0.001).Conclusion: Both the presence and rate of change of sarcopenia are independently associated with long-term mortality in patients with liver cirrhosis.
URI
https://jkms.org/DOIx.php?id=10.3346/jkms.2018.33.e299http://repository.hanyang.ac.kr/handle/20.500.11754/121151
ISSN
1011-8934; 1598-6357
DOI
10.3346/jkms.2018.33.e299
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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