Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 전대원 | - |
dc.date.accessioned | 2019-12-10T20:06:58Z | - |
dc.date.available | 2019-12-10T20:06:58Z | - |
dc.date.issued | 2018-12 | - |
dc.identifier.citation | MEDICINE, v. 97, no. 50, Article no. e13636 | en_US |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.issn | 1536-5964 | - |
dc.identifier.uri | https://insights.ovid.com/crossref?an=00005792-201812140-00093 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/121150 | - |
dc.description.abstract | The controlled attenuation parameter (CAP) has shown a good correlation with the intrahepatic fat amount in cross-sectional studies. However, there is no study on whether the change of CAP scores can also show good correlation in a longitudinal setting. Therefore, we investigated the correlation between CAP and magnetic resonance imaging-estimated proton density fat fraction (MR PDFF) through serial examination in a longitudinal setting.Sixty-five patients with nonalcoholic fatty liver disease were evaluated with MR PDFF and transient elastography including CAP at baseline and 3 months later.The CAP and MR PDFF at baseline showed a strong correlation in assessing hepatic steatosis (r=0.66, P<. 001). After treatment, the correlation between the change in CAP after treatment and the intrahepatic fat change (%) on MR PDFF was not satisfactory (r=0.37, P=.005) in the longitudinal setting. The optimal cutoff value of the change in CAP for discriminating an improvement or an aggravation in intrahepatic fat percentage (>1% change in MR PDFF) was selected as 38dB/m (area under the receiver operating characteristic curve=0.559). For CAP changes>38dB/m, the predictive value was 14/16 (87.5%), whereas for changes< 38dB/m, the predictive value was 12/41 (29.3%). Thereby, the accuracy of the method using the change in CAP was only 26/57 (46%). In addition, Cohen's kappa value was not significant (k=0.11, P=.186).Careful interpretation of the steatosis change based on the CAP score is needed when the absolute change value is< 38dB/m in a longitudinal setting. | en_US |
dc.description.sponsorship | This study was supported by a grant from the National Research Foundation of Korea (2011-0007127). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | en_US |
dc.subject | controlled attenuation parameter | en_US |
dc.subject | fatty liver | en_US |
dc.subject | hepatic steatosis | en_US |
dc.title | Optimal cutoff value for assessing changes in intrahepatic fat amount by using the controlled attenuation parameter in a longitudinal setting | en_US |
dc.type | Article | en_US |
dc.relation.no | 50 | - |
dc.relation.volume | 97 | - |
dc.identifier.doi | 10.1097/MD.0000000000013636 | - |
dc.relation.page | 1-10 | - |
dc.relation.journal | MEDICINE | - |
dc.contributor.googleauthor | Ahn, Sang Bong | - |
dc.contributor.googleauthor | Jun, Dae Won | - |
dc.contributor.googleauthor | Kang, Bo-kyeong | - |
dc.contributor.googleauthor | Kim, Mimi | - |
dc.contributor.googleauthor | Chang, Misoo | - |
dc.contributor.googleauthor | Nam, Eunwoo | - |
dc.relation.code | 2018002227 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | noshin | - |
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