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Optimal cutoff value for assessing changes in intrahepatic fat amount by using the controlled attenuation parameter in a longitudinal setting

Title
Optimal cutoff value for assessing changes in intrahepatic fat amount by using the controlled attenuation parameter in a longitudinal setting
Author
전대원
Keywords
controlled attenuation parameter; fatty liver; hepatic steatosis
Issue Date
2018-12
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
MEDICINE, v. 97, no. 50, Article no. e13636
Abstract
The controlled attenuation parameter (CAP) has shown a good correlation with the intrahepatic fat amount in cross-sectional studies. However, there is no study on whether the change of CAP scores can also show good correlation in a longitudinal setting. Therefore, we investigated the correlation between CAP and magnetic resonance imaging-estimated proton density fat fraction (MR PDFF) through serial examination in a longitudinal setting.Sixty-five patients with nonalcoholic fatty liver disease were evaluated with MR PDFF and transient elastography including CAP at baseline and 3 months later.The CAP and MR PDFF at baseline showed a strong correlation in assessing hepatic steatosis (r=0.66, P<. 001). After treatment, the correlation between the change in CAP after treatment and the intrahepatic fat change (%) on MR PDFF was not satisfactory (r=0.37, P=.005) in the longitudinal setting. The optimal cutoff value of the change in CAP for discriminating an improvement or an aggravation in intrahepatic fat percentage (>1% change in MR PDFF) was selected as 38dB/m (area under the receiver operating characteristic curve=0.559). For CAP changes>38dB/m, the predictive value was 14/16 (87.5%), whereas for changes< 38dB/m, the predictive value was 12/41 (29.3%). Thereby, the accuracy of the method using the change in CAP was only 26/57 (46%). In addition, Cohen's kappa value was not significant (k=0.11, P=.186).Careful interpretation of the steatosis change based on the CAP score is needed when the absolute change value is< 38dB/m in a longitudinal setting.
URI
https://insights.ovid.com/crossref?an=00005792-201812140-00093http://repository.hanyang.ac.kr/handle/20.500.11754/121150
ISSN
0025-7974; 1536-5964
DOI
10.1097/MD.0000000000013636
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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