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dc.contributor.author신진호-
dc.date.accessioned2019-12-10T19:49:26Z-
dc.date.available2019-12-10T19:49:26Z-
dc.date.issued2018-12-
dc.identifier.citationHYPERTENSION, v. 72, no. 6, page. 1285-1293en_US
dc.identifier.issn0194-911X-
dc.identifier.issn1524-4563-
dc.identifier.urihttps://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.11787-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/121125-
dc.description.abstractEvidence about the benefits of treating uncomplicated, low-risk, stage-1 hypertension is lacking. The study aimed to investigate the association between mean blood pressure (BP) and clinical outcomes, and to determine optimal BPs in treated, low-risk, stage-1 hypertension. From the National Health Insurance Service Health Examination Database, patients with stage-1 hypertension between 2005 and 2006 were selected. They had a systolic BP of 140 to 159 mmHg or diastolic BP of 90 to 99 mmHg. Patients were grouped as controlled (mean BP <140/90 mmHg; n=99301) and uncontrolled (mean BP 140/90 mmHg; n=49460) according to their mean BP recorded during the follow-up health examination. All-cause mortality and cardiovascular outcomes were examined. Mean BPs in the controlled and uncontrolled groups were 131.1/80.9 and 144.6/86.8 mmHg, respectively. Controlled BP was associated with significantly lower risks of all-cause mortality, all stroke, hemorrhagic stroke, ischemic stroke, and end-stage renal disease. Subgroup analysis demonstrated benefits of controlled BP in hypertensive patients aged <50 years for all-cause mortality, all stroke, hemorrhagic stroke, ischemic stroke, and end-stage renal disease, with no significant interaction according to age. The BP associated with the lowest risk of all-cause mortality was 120 to <130 mmHg (systolic BP) and 70 to <80 mmHg (diastolic BP). There was an increased risk of myocardial infarction in patients with mean systolic BP <120 mmHg and diastolic BP <80 mmHg. BP <140/90 mmHg was associated with a significant reduction in the risk of mortality, stroke, and end-stage renal disease, with the lowest mortality risk at BP ranges of 120 to <130 and 70 to <80 mmHg.en_US
dc.description.sponsorshipThis research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health and Welfare, Republic of Korea (grant number HI13C0715).en_US
dc.language.isoen_USen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.subjectblood pressureen_US
dc.subjecthypertensionen_US
dc.subjectmortalityen_US
dc.subjectmyocardial infarctionen_US
dc.subjectstrokeen_US
dc.titleClinical Benefit of Treatment of Stage-1, Low-Risk Hypertension: Korean National Health Insurance Database Analysisen_US
dc.typeArticleen_US
dc.relation.no6-
dc.relation.volume72-
dc.identifier.doi10.1161/HYPERTENSIONAHA.118.11787-
dc.relation.page1285-1293-
dc.relation.journalHYPERTENSION-
dc.contributor.googleauthorLee, Chan Joo-
dc.contributor.googleauthorRyu, Jiin-
dc.contributor.googleauthorKim, Hyeon-Chang-
dc.contributor.googleauthorRyu, Dong-Ryeol-
dc.contributor.googleauthorIhm, Sang-Hyun-
dc.contributor.googleauthorKim, Yong-Jin-
dc.contributor.googleauthorShin, Jin-Ho-
dc.contributor.googleauthorPyun, Wook Bum-
dc.contributor.googleauthorKang, Hyoung-Soo-
dc.contributor.googleauthorPark, Jong-Heon-
dc.relation.code2018000923-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidjhs2003-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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