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dc.contributor.author하태경-
dc.date.accessioned2019-12-10T16:55:15Z-
dc.date.available2019-12-10T16:55:15Z-
dc.date.issued2018-12-
dc.identifier.citationANNALS OF SURGICAL TREATMENT AND RESEARCH, v. 95, no. 6, page. 312-318en_US
dc.identifier.issn2288-6575-
dc.identifier.issn2288-6796-
dc.identifier.urihttps://www.astr.or.kr/DOIx.php?id=10.4174/astr.2018.95.6.312-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/121058-
dc.description.abstractPurpose: Acute normovolemic hemodilution (ANH) is an autologous transfusion method, using blood collected during surgery, to reduce the need for allogeneic blood transfusion. ANH is controversial because it may lead to various complications. Among the possible complications, anastomotic leakage is one that would have a significant effect on the operation outcome. However, the relationship between ANH and anastomotic site healing requires additional research. Therefore, we conducted this prospective study of ANH, comparing it with standard intraoperative management, undergoing gastric anastomosis in rats.Methods: Sixteen Sprague-Dawley rats were randomly assigned to three groups: group A, surgery with ANH; group N, surgery with standard intraoperative management; and group C, sham surgery with standard intraoperative management. ANH was performed in group A animals by, removing 5.8-6.6 mL of blood and replacing it with 3 times as much crystalloid. All rats were enthanized on postoperative day 6, and histopathologic analyses were performed.Results: The mean hematocrit values, after hemodilution were 22.0% (range, 18.0%-29.0%), group A; 33.0% (29.0%-35.0%), group N; and 32.5% (29.0%-34.0%), group C. There were significant differences between groups A and N (P = 0.019, P = 0.009, P = 0.004, P = 0.039, and P = 0.027), and between groups N and C (P = 0.006, P = 0.027, P = 0.04, P = 0.008, and P = 0.009) with respect to inflammatory cell numbers, neovascularization, fibroblast numbers, edema and necrosis, respectively; there were no differences between groups A and N.Conclusion: In rat model, anastomotic complications did not increase in the ANH group, compared with the standard intraoperative management group.en_US
dc.language.isoen_USen_US
dc.publisherKOREAN SURGICAL SOCIETYen_US
dc.subjectHemodilutionen_US
dc.subjectAnastomotic leaken_US
dc.subjectExperimental animal modelen_US
dc.titleEffects of acute normovolemic hemodilution on healing of gastric anastomosis in ratsen_US
dc.typeArticleen_US
dc.relation.no6-
dc.relation.volume95-
dc.identifier.doi10.4174/astr.2018.95.6.312-
dc.relation.page312-318-
dc.relation.journalANNALS OF SURGICAL TREATMENT AND RESEARCH-
dc.contributor.googleauthorKim, Tae Yeon-
dc.contributor.googleauthorKim, Dong Won-
dc.contributor.googleauthorJeong, Mi Ae-
dc.contributor.googleauthorJun, Jong Hun-
dc.contributor.googleauthorMin, Sung Jeong-
dc.contributor.googleauthorShin, Su-Jin-
dc.contributor.googleauthorHa, Tae Kyung-
dc.contributor.googleauthorChoi, Dongho-
dc.relation.code2018012676-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidmissurgeon-


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