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Cerebrolysin for the Treatment of Aneurysmal Subarachnoid Hemorrhage in Adults: A Retrospective Chart Review

Title
Cerebrolysin for the Treatment of Aneurysmal Subarachnoid Hemorrhage in Adults: A Retrospective Chart Review
Author
김동원
Keywords
Aneurysmal subarachnoid hemorrhage; Brain hemorrhage; Cerebrolysin; Cerebrovascular disorders; Neuroprotective agents; Mortality
Issue Date
2018-12
Publisher
SPRINGER
Citation
ADVANCES IN THERAPY, v. 35, no. 12, page. 2224-2235
Abstract
IntroductionCerebrolysin is a neuroprotective drug used in the treatment of acute ischemic stroke. To our knowledge, this drug has never been evaluated in patients with aneurysmal subarachnoid hemorrhage (SAH). The aim of this study was to evaluate the effect of Cerebrolysin in patients with aneurysmal SAH.MethodsAneurysmal SAH patients who had their aneurysm obliterated at our institution from 2007 to 2016 were retrospectively studied. Patients received Cerebrolysin treatment or standard care only (control group). Subgroup analyses were performed according to Hunt and Hess grade (good grade2, N=216; poor grade3, N=246) and treatment procedure (clip or coil).ResultsIn good-grade patients (N=216), clinical outcomes and mortality did not differ significantly between the control and Cerebrolysin groups. In poor-grade patients (N=246), the mortality rate was significantly lower in the Cerebrolysin group (8.7%) than in the control group (25.4%, p=0.006). In patients who received microsurgical clipping (N=328), the mortality rate was significantly lower in the Cerebrolysin group (7.3%) than in the control group (18.5%, p=0.016).ConclusionCerebrolysin injection during the acute period of SAH appeared to reduce the mortality rate, especially in poor-grade patients. This study suggests the potential of Cerebrolysin for treating aneurysmal SAH. Further studies are needed to confirm our results.
URI
https://link.springer.com/article/10.1007%2Fs12325-018-0832-8http://repository.hanyang.ac.kr/handle/20.500.11754/121011
ISSN
0741-238X; 1865-8652
DOI
10.1007/s12325-018-0832-8
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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