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dc.contributor.author문효방-
dc.date.accessioned2019-12-10T06:21:05Z-
dc.date.available2019-12-10T06:21:05Z-
dc.date.issued2019-07-
dc.identifier.citationENVIRONMENTAL SCIENCE & TECHNOLOGY, v. 53, No. 17, Page. 10043-10052en_US
dc.identifier.issn0013-936X-
dc.identifier.issn1520-5851-
dc.identifier.urihttps://pubs.acs.org/doi/abs/10.1021/acs.est.9b02166-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/120855-
dc.description.abstractEffect-directed analysis was used to identify previously unidentified aryl hydrocarbon receptor (AhR) agonists in sediments collected from a highly industrialized area of Ulsan Bay, Korea. The specific objectives were to (i) investigate potent fractions of sediment extracts using the H4IIE-luc bioassay, (ii) determine the concentrations of known AhR agonists (polycyclic aromatic hydrocarbons (PAHs) and styrene oligomers (SOs)), (iii) identify previously unreported AhR agonists in fractions by use of GC-QTOFMS, and (iv) evaluate contributions of individual compounds to overall AhR-mediated potencies, found primarily in fractions containing aromatics with log K-ow 5-8. Greater concentrations of PAHs and SOs were also found in those fractions. On the basis of GC-QTOFMS and GC-MSD analyses, 16 candidates for AhR agonists were identified in extracts of sediments. Of these, seven compounds, including 1-methylchrysene, benzo[j]fluoranthene, 3-methylchrysene, 5-methylbenz[a]anthracene, 11H-benzo[b]fluorene, benzo[b]-naphtho[2,3-d]furan, and benzo[b]naphtho[2,1-d]thiophene, exhibited significant AhR activity. Relative potency values of newly identified AhR agonists were found to be greater than or comparable to that of benzo[a]pyrene (BaP). The potency balance analysis showed that newly identified AhR agonists explained 0.07-16% of bioassay-derived BaP-EQs. These chemicals were widely distributed in industrial sediments; thus, it is of immediate importance to conduct studies on sources and potential effects of those chemicals.en_US
dc.description.sponsorshipThis work was supported by National Research Foundation of Korea (NRF) grants funded by the Korean government (MSIP) (2017R1A4A1015393, 2016R1E1A1A01943004, and 2017R1E1A1A01075067). This work was also supported by the projects entitled "Development of techniques for assessment and management of hazardous chemicals in the marine environment (20I4-0342)" and "Marine ecosystem -based analysis and decision -making support system development for marine spatial planning (2017-0325)" funded by the Ministry of Oceans and Fisheries of Korea.en_US
dc.language.isoen_USen_US
dc.publisherAMER CHEMICAL SOCen_US
dc.titleNewly Identified AhR-Active Compounds in the Sediments of an Industrial Area Using Effect-Directed Analysisen_US
dc.typeArticleen_US
dc.relation.no17-
dc.relation.volume53-
dc.identifier.doi10.1021/acs.est.9b02166-
dc.relation.page10043-10052-
dc.relation.journalENVIRONMENTAL SCIENCE & TECHNOLOGY-
dc.contributor.googleauthorKim, Jaeseong-
dc.contributor.googleauthorHong, Seongjin-
dc.contributor.googleauthorCha, Jihyun-
dc.contributor.googleauthorLee, Junghyun-
dc.contributor.googleauthorKim, Taewoo-
dc.contributor.googleauthorLee, Sunggyu-
dc.contributor.googleauthorMoon, Hyo-Bang-
dc.contributor.googleauthorShin, Kyung-Hoon-
dc.contributor.googleauthorHur, Jin-
dc.contributor.googleauthorLee, Jung-Suk-
dc.contributor.googleauthorGiesy, John P.-
dc.contributor.googleauthorKhim, Jong Seong-
dc.relation.code2019001173-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E]-
dc.sector.departmentDEPARTMENT OF MARINE SCIENCE AND CONVERGENCE ENGINEERING-
dc.identifier.pidhbmoon-


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