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Optical coherence tomography angiography analysis of changes in the retina and the choroid after haemodialysis

Title
Optical coherence tomography angiography analysis of changes in the retina and the choroid after haemodialysis
Author
성민철
Keywords
INTRAOCULAR-PRESSURE; DIABETIC-RETINOPATHY; MACULAR THICKNESS; AUTOREGULATION; CIRCULATION; ARTIFACTS
Issue Date
2018-11
Publisher
NATURE PUBLISHING GROUP
Citation
SCIENTIFIC REPORTS, v. 8, Article no. 17184
Abstract
The purpose of this study is to evaluate the effect of haemodialysis on perfused vessel density, choroidal thickness (CT), and retinal thickness in end-stage renal disease (ESRD) using swept-source optical coherence tomography angiography (SS-OCTA). We studied twenty-nine eyes of 29 ESRD patients by ophthalmologic examination and SS-OCTA before and after haemodialysis. The colour-coded perfusion density maps were generated and perfused vessel density was calculated. Changes in systemic and other ocular parameters such as retinal and choroidal thickness were measured and analysed. Total perfused vessel density decreased significantly after haemodialysis in the choriocapillaris; it was not significantly different in the superficial capillary plexus (SCP) and the deep capillary plexus (DCP). Total CT decreased significantly, but total retinal thickness was not significantly different. There was no significant correlation between choriocapillaris perfused vessel density and CT. The reduction in choriocapillaris perfused vessel density correlated with the decrease in systolic and mean arterial blood pressures. The decrease in CT correlated with the ultrafiltration volume. There were no significant systemic and ocular factors affecting change in retinal thickness and perfused vessel density of SCP and DCP. This is the first study to assess the effect of haemodialysis on blood flow changes using SS-OCTA; changes may be more prominent in the choroidal compared to the retinal layer.
URI
https://www.nature.com/articles/s41598-018-35562-6http://repository.hanyang.ac.kr/handle/20.500.11754/120751
ISSN
2045-2322
DOI
10.1038/s41598-018-35562-6
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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