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Poly-gamma-glutamic acid suppresses osteoclastogenesis in human osteoclast precursors and prevents joint damage in a collagen-induced murine arthritis model

Title
Poly-gamma-glutamic acid suppresses osteoclastogenesis in human osteoclast precursors and prevents joint damage in a collagen-induced murine arthritis model
Author
김태환
Keywords
Poly-gamma-glutamic acid (gamma-PGA); Osteoclast; Rheumatoid arthritis
Issue Date
2018-11
Publisher
ELSEVIER SCIENCE BV
Citation
IMMUNOLOGY LETTERS, v. 203, page. 80-86
Abstract
Poly-gamma-glutamic acid (gamma-PGA), a natural polymer derived from Bacillus subtilis, shows anti-inflammatory activity. However, the effects of gamma-PGA on osteoclasts, which are important cells for joint destruction in inflammatory diseases such as rheumatoid arthritis (RA), have not yet been reported. In this study, we show that gamma-PGA markedly inhibits osteoclast differentiation in normal PBMC-derived osteoclast precursors and in synovial fluid macrophages of patients with RA. gamma-PGA also reduces RANK expression by down-regulating M-CSF receptors. Additionally, oral administration of gamma-PGA attenuated bone destruction in a collagen-induced arthritis (CIA) model, demonstrating decreases in inflammation, cartilage damage, and osteoclast formation in histological analyses. Taken together, these data suggest that gamma-PGA could be a good candidate for therapeutic prevention of joint destruction in RA.
URI
https://www.sciencedirect.com/science/article/abs/pii/S0165247818302104?via%3Dihubhttp://repository.hanyang.ac.kr/handle/20.500.11754/120714
ISSN
0165-2478; 1879-0542
DOI
10.1016/j.imlet.2018.09.004
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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