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Amino acid position 37 of HLA-DR beta 1 affects susceptibility to Crohn's disease in Asians

Title
Amino acid position 37 of HLA-DR beta 1 affects susceptibility to Crohn's disease in Asians
Author
김태환
Keywords
INFLAMMATORY-BOWEL-DISEASE; ULCERATIVE-COLITIS; HLA ALLELES; ASSOCIATION; RISK; LOCI; MHC; INTRACTABILITY; PROTEINS; DQ
Issue Date
2018-11
Publisher
OXFORD UNIV PRESS
Citation
HUMAN MOLECULAR GENETICS, v. 27, no. 22, page. 3901-3910
Abstract
Crohn's disease (CD) and ulcerative colitis (UC) are the major types of chronic inflammatory bowel disease (IBD) characterized by recurring episodes of inflammation of the gastrointestinal tract. Although it is well established that human leukocyte antigen (HLA) is a major risk factor for IBD, it is yet to be determined which HLA alleles or amino acids drive the risks of CD and UC in Asians. To define the roles of HLA for IBD in Asians, we fine-mapped HLA in 12 568 individuals from Korea and Japan (3294 patients with CD, 1522 patients with UC and 7752 controls). We identified that the amino acid position 37 of HLA-DR beta 1 plays a key role in the susceptibility to CD (presence of serine being protective, P = 3.6 x 10(-67), OR = 0.48 [0.45-0.52]). For UC, we confirmed the known association of the haplotype spanning HLA-C*12:02, HLA-B*52:01 and HLA-DRB1*1502 (P = 1.2 x 10(-28), OR = 4.01 [3.14-5.12]).
URI
https://academic.oup.com/hmg/article-abstract/27/22/3901/5061929?redirectedFrom=fulltexthttp://repository.hanyang.ac.kr/handle/20.500.11754/120713
ISSN
0964-6906; 1460-2083
DOI
10.1093/hmg/ddy285
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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