Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 민경환 | - |
dc.date.accessioned | 2019-12-09T20:14:49Z | - |
dc.date.available | 2019-12-09T20:14:49Z | - |
dc.date.issued | 2018-10 | - |
dc.identifier.citation | HUMAN PATHOLOGY, v. 80, page. 28-39 | en_US |
dc.identifier.issn | 0046-8177 | - |
dc.identifier.issn | 1532-8392 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0046817718301175?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/120451 | - |
dc.description.abstract | Programmed cell death-1 ligand-1 (PD-L1), essential for immune evasion, is a potential candidate for pathogenesis and therapeutic target of human papillomavirus (HPV)-positive tonsillar squamous cell carcinomas (TSCCs). MET/hepatocyte growth factor signaling and transcription factors involved in epithelial-to-mesenchymal transition (EMT) upregulate PD-L1, which can contribute to clinical outcome. Intratumoral heterogeneity of PD-L1 expression is of clinical importance in selection bias due to false-negative patient enrollment. However, the clinicopathological features, prognostic value, and coexpressed molecules of PD-L1 remain unclear in TSCCs. PD-L1 expression was evaluated via immunohistochemistry using a specific monoclonal antibody (SP142) between whole-tissue and tissue microarray (TMA) sections of 79 tumors (5% cutoff value with weak staining). Expressions of EMT markers (TWIST1, Snail, and SNIP1) and MET/hepatocyte growth factor were also analyzed. Staining of the TMA sections showed 78.5% concordance rate to the whole section. PD-L1 positivity and its intratumoral heterogeneity were 29.1% and 15.2% of TSCCs by whole section, respectively. PD-L1 positivity was prevalent in females, HPV-positive tumors without base of tongue invasion, and SNIP1-overexpressed tumors. SNIP1 overexpression, unmethylated TWIST1, smoking, and poorly differentiated tumors were predictive for PD-L1 overexpression. PD-L1 positivity was a favorable independent prognostic factor. Subgroup analyses according to the coexpression of PD-L1 with HPV, SNIP], or unmethylated TWIST1 indicated the best clinical outcome than any other subgroups. In conclusion, intratumoral heterogeneity of PD-L1 expression was frequent, warranting a caution in punching TMA cores. A combined analysis of PD-L1 with EMT and HPV may define a characteristic subset of patients and prognostic group. (C) 2018 The Authors. Published by Elsevier Inc. | en_US |
dc.description.sponsorship | This research was supported by the Hallym University Research Fund (HURF-2017-38) and by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2016R1D1A1B03935447) to M. J. Kwon. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | W B SAUNDERS CO-ELSEVIER INC | en_US |
dc.subject | Programmed cell death-1 ligand-1 | en_US |
dc.subject | Tonsil | en_US |
dc.subject | Squamous cell carcinoma | en_US |
dc.subject | Human papillomavirus | en_US |
dc.subject | Epithelial-to-mesenchymal transition | en_US |
dc.title | Clinical implication of programmed cell death-1 ligand-1 expression in tonsillar squamous cell carcinoma in association with intratumoral heterogeneity, human papillomavirus, and epithelial-to-mesenchymal transition | en_US |
dc.type | Article | en_US |
dc.relation.volume | 80 | - |
dc.identifier.doi | 10.1016/j.humpath.2018.03.025 | - |
dc.relation.page | 28-39 | - |
dc.relation.journal | HUMAN PATHOLOGY | - |
dc.contributor.googleauthor | Kwon, Mi Jung | - |
dc.contributor.googleauthor | Rho, Young-Soo | - |
dc.contributor.googleauthor | Nam, Eun Sook | - |
dc.contributor.googleauthor | Cho, Seong Jin | - |
dc.contributor.googleauthor | Park, Hye-Rim | - |
dc.contributor.googleauthor | Min, Soo Kee | - |
dc.contributor.googleauthor | Seo, Jinwon | - |
dc.contributor.googleauthor | Choe, Ji-Young | - |
dc.contributor.googleauthor | Kim, Eun Soo | - |
dc.contributor.googleauthor | Min, Kyueng-Whan | - |
dc.relation.code | 2018003655 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | kyueng | - |
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