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Role of the CCN protein family in cancer

Title
Role of the CCN protein family in cancer
Author
신인철
Keywords
Cancer; CCN family; Matricellular protein; Signal transduction; Therapeutic target
Issue Date
2018-10
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Citation
BMB REPORTS, v. 51, no. 10, page. 486-492
Abstract
The CCN protein family is composed of six matricellular proteins, which serve regulatory roles rather than structural roles in the extracellular matrix. First identified as secreted proteins which are induced by oncogenes, the acronym CCN came from the names of the first three members: CYR61, CTGF, and NOV. All six members of the CCN family consist of four cysteine-rich modular domains. CCN proteins are known to regulate cell adhesion, proliferation, differentiation, and apoptosis. In addition, CCN proteins are associated with cardiovascular and skeletal development, injury repair, inflammation, and cancer. They function either through binding to integrin receptors or by regulating the expression and activity of growth factors and cytokines. Given their diverse roles related to the pathology of certain diseases such as fibrosis, arthritis, atherosclerosis, diabetic nephropathy, retinopathy, and cancer, there are many emerging studies targeting CCN protein signaling pathways in attempts to elucidate their potentials as therapeutic targets.
URI
http://www.bmbreports.org/journal/view.html?doi=10.5483/BMBRep.2018.51.10.192http://repository.hanyang.ac.kr/handle/20.500.11754/120400
ISSN
1976-6696; 1976-670X
DOI
10.5483/BMBRep.2018.51.10.192
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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