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Intranasal delivery of a Fas-blocking peptide attenuates Fas-mediated apoptosis in brain ischemia

Title
Intranasal delivery of a Fas-blocking peptide attenuates Fas-mediated apoptosis in brain ischemia
Author
이민형
Keywords
NASAL DRUG-DELIVERY; GLUCOSE-TRANSPORTER; STROKE; MECHANISMS; BARRIER; TARGET; SIRNA; CELL; MEMBRANES; NECROSIS
Issue Date
2018-10
Publisher
NATURE PUBLISHING GROUP
Citation
SCIENTIFIC REPORTS, v. 8, Article no. 15041
Abstract
Ischemic stroke-induced neuronal cell death results in the permanent disabling of brain function. Apoptotic mechanisms are thought to play a prominent role in neuronal injury and ample evidence implicates Fas signaling in mediating cell death. In this study, we describe the neuroprotective effects of a Fas-blocking peptide (FBP) that by obstructing Fas signaling in cerebral ischemia inhibits apoptosis. Using an intranasal administration route in a rat model of focal cerebral ischemia, we demonstrate that nose-to-brain delivery of FBP after middle cerebral artery occlusion (MCAO) surgery results in the delivery and retention of FBP in Fas-expressing ischemic areas of the brain. A single intranasal administration of 2 mg/kg FBP resulted in significantly reduced neuronal cell death by inhibiting Fas-mediated apoptosis leading to decreased infarct volumes, reduced neurologic deficit scores and recovery from cerebral ischemia. Intranasally delivered FBP might be a promising strategy for the treatment of cerebral ischemic stroke.
URI
https://www.nature.com/articles/s41598-018-33296-zhttp://repository.hanyang.ac.kr/handle/20.500.11754/120337
ISSN
2045-2322
DOI
10.1038/s41598-018-33296-z
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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