Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 채필석 | - |
dc.date.accessioned | 2019-12-09T17:20:00Z | - |
dc.date.available | 2019-12-09T17:20:00Z | - |
dc.date.issued | 2018-10 | - |
dc.identifier.citation | CHEMBIOCHEM, v. 19, no. 20, page. 2225-2232 | en_US |
dc.identifier.issn | 1439-4227 | - |
dc.identifier.issn | 1439-7633 | - |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/abs/10.1002/cbic.201800388 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/120277 | - |
dc.description.abstract | A new family of tandem facial glucosides/maltosides (TFGs/TFMs) for membrane protein manipulation was prepared. The best detergent varied depending on the hydrophobic thickness of the target protein, but ether-based TFMs (TFM-C0E, TFM-C3E, and TFM-C5E) were notable for their ability to confer higher membrane protein stability than the previously developed amide-based TFA-1 (P.S. Chae, K. Gotfryd, J. Pacyna, L.J.W. Miercke, S.G.F. Rasmussen, R.A. Robbins, R.R. Rana, C.J. Loland, B. Kobilka, R. Stroud, B. Byrne, U. Gether, S.H. Gellman, ). Thus, this study not only introduces novel agents with the potential to be used in membrane protein research but also highlights the importance of both the hydrophobic length and linker functionality of the detergent in stabilizing membrane proteins. | en_US |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (grant number 2016R1A2B2011257 to P.S.C.). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | WILEY-V C H VERLAG GMBH | en_US |
dc.subject | detergent design | en_US |
dc.subject | detergent faciality | en_US |
dc.subject | amphiphiles | en_US |
dc.subject | protein stabilization | en_US |
dc.subject | protein structures | en_US |
dc.title | Rationally Engineered Tandem Facial Amphiphiles for Improved Membrane Protein Stabilization Efficacy | en_US |
dc.type | Article | en_US |
dc.relation.no | 20 | - |
dc.relation.volume | 19 | - |
dc.identifier.doi | 10.1002/cbic.201800388 | - |
dc.relation.page | 2225-2232 | - |
dc.relation.journal | CHEMBIOCHEM | - |
dc.contributor.googleauthor | Das, Manabendra | - |
dc.contributor.googleauthor | Du, Yang | - |
dc.contributor.googleauthor | Mortensen, Jonas S. | - |
dc.contributor.googleauthor | Hariharan, Parameswaran | - |
dc.contributor.googleauthor | Lee, Hyun Sung | - |
dc.contributor.googleauthor | Byrne, Bernadette | - |
dc.contributor.googleauthor | Loland, Claus J. | - |
dc.contributor.googleauthor | Guan, Lan | - |
dc.contributor.googleauthor | Kobilka, Brian K. | - |
dc.contributor.googleauthor | Chae, Pil Seok | - |
dc.relation.code | 2018001478 | - |
dc.sector.campus | S | - |
dc.sector.daehak | GRADUATE SCHOOL[S] | - |
dc.sector.department | DEPARTMENT OF BIONANOTECHNOLOGY | - |
dc.identifier.pid | pchae | - |
dc.identifier.orcid | http://orcid.org/0000-0003-1799-3304 | - |
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