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Rationally Engineered Tandem Facial Amphiphiles for Improved Membrane Protein Stabilization Efficacy

Title
Rationally Engineered Tandem Facial Amphiphiles for Improved Membrane Protein Stabilization Efficacy
Author
채필석
Keywords
detergent design; detergent faciality; amphiphiles; protein stabilization; protein structures
Issue Date
2018-10
Publisher
WILEY-V C H VERLAG GMBH
Citation
CHEMBIOCHEM, v. 19, no. 20, page. 2225-2232
Abstract
A new family of tandem facial glucosides/maltosides (TFGs/TFMs) for membrane protein manipulation was prepared. The best detergent varied depending on the hydrophobic thickness of the target protein, but ether-based TFMs (TFM-C0E, TFM-C3E, and TFM-C5E) were notable for their ability to confer higher membrane protein stability than the previously developed amide-based TFA-1 (P.S. Chae, K. Gotfryd, J. Pacyna, L.J.W. Miercke, S.G.F. Rasmussen, R.A. Robbins, R.R. Rana, C.J. Loland, B. Kobilka, R. Stroud, B. Byrne, U. Gether, S.H. Gellman, ). Thus, this study not only introduces novel agents with the potential to be used in membrane protein research but also highlights the importance of both the hydrophobic length and linker functionality of the detergent in stabilizing membrane proteins.
URI
https://onlinelibrary.wiley.com/doi/abs/10.1002/cbic.201800388http://repository.hanyang.ac.kr/handle/20.500.11754/120277
ISSN
1439-4227; 1439-7633
DOI
10.1002/cbic.201800388
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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