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dc.contributor.author김기현-
dc.date.accessioned2019-12-09T07:11:53Z-
dc.date.available2019-12-09T07:11:53Z-
dc.date.issued2018-09-
dc.identifier.citationTRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 106, page. 159-168en_US
dc.identifier.issn0165-9936-
dc.identifier.issn1879-3142-
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S0165993618301717?via%3Dihub-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/120152-
dc.description.abstractNeurochemicals are mainly distributed in the central nervous system, and related to various neurological functions and disorders. Because neurochemicals are biosynthesized and metabolized through multiple pathways, it is difficult to understand the overall nervous system or to diagnose neurological disorders based on certain neurochemical levels. Therefore, to learn more about the nervous system and neurological disorders, metabolomics approaches should be used to profile the metabolic pathways of neurochemicals. To date, the neurochemical profiling has been pursued by various methods, especially including mass spectrometry (MS) coupled with conventional chromatographic techniques, which can sensitively and selectively determine numerous neurochemicals in biological samples. Nevertheless, the development of chromatographic MS-based analytical platforms to profile neurochemicals in biological samples has faced several challenges. This review was organized to help characterize neurochemicals using descriptions of the basic procedures (sample preparation and chromatographic MS detection). Moreover, we describe clinical applications and performance evaluation of these techniques. (C) 2018 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipThis research was supported by the National Research Foundation of Korea (NRF-2017R1A2B4005616 and 2017M3A9F3047858). This study was also supported by grants from the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (Grant No: 2016R1E1A1A01940995).en_US
dc.language.isoen_USen_US
dc.publisherELSEVIER SCI LTDen_US
dc.subjectNeurochemicalsen_US
dc.subjectNervous systemen_US
dc.subjectBiological samplesen_US
dc.subjectProfiling analysisen_US
dc.subjectMass spectrometryen_US
dc.subjectGas chromatographyen_US
dc.subjectLiquid chromatographyen_US
dc.titleAdvances and challenges in neurochemical profiling of biological samples using mass spectrometry coupled with separation methodsen_US
dc.typeArticleen_US
dc.relation.volume106-
dc.identifier.doi10.1016/j.trac.2018.07.006-
dc.relation.page159-168-
dc.relation.journalTRAC-TRENDS IN ANALYTICAL CHEMISTRY-
dc.contributor.googleauthorLee, Wonwoong-
dc.contributor.googleauthorPark, Na Hyun-
dc.contributor.googleauthorLee, Yong Chan-
dc.contributor.googleauthorKim, Ki-Hyun-
dc.contributor.googleauthorHong, Jongki-
dc.relation.code2018001504-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF ENGINEERING[S]-
dc.sector.departmentDEPARTMENT OF CIVIL AND ENVIRONMENTAL ENGINEERING-
dc.identifier.pidkkim61-
dc.identifier.researcherIDI-8499-2018-
dc.identifier.orcidhttps://orcid.org/0000-0003-0487-4242-
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COLLEGE OF ENGINEERING[S](공과대학) > CIVIL AND ENVIRONMENTAL ENGINEERING(건설환경공학과) > Articles
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