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Advances and challenges in neurochemical profiling of biological samples using mass spectrometry coupled with separation methods

Title
Advances and challenges in neurochemical profiling of biological samples using mass spectrometry coupled with separation methods
Author
김기현
Keywords
Neurochemicals; Nervous system; Biological samples; Profiling analysis; Mass spectrometry; Gas chromatography; Liquid chromatography
Issue Date
2018-09
Publisher
ELSEVIER SCI LTD
Citation
TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 106, page. 159-168
Abstract
Neurochemicals are mainly distributed in the central nervous system, and related to various neurological functions and disorders. Because neurochemicals are biosynthesized and metabolized through multiple pathways, it is difficult to understand the overall nervous system or to diagnose neurological disorders based on certain neurochemical levels. Therefore, to learn more about the nervous system and neurological disorders, metabolomics approaches should be used to profile the metabolic pathways of neurochemicals. To date, the neurochemical profiling has been pursued by various methods, especially including mass spectrometry (MS) coupled with conventional chromatographic techniques, which can sensitively and selectively determine numerous neurochemicals in biological samples. Nevertheless, the development of chromatographic MS-based analytical platforms to profile neurochemicals in biological samples has faced several challenges. This review was organized to help characterize neurochemicals using descriptions of the basic procedures (sample preparation and chromatographic MS detection). Moreover, we describe clinical applications and performance evaluation of these techniques. (C) 2018 Elsevier B.V. All rights reserved.
URI
https://www.sciencedirect.com/science/article/abs/pii/S0165993618301717?via%3Dihubhttp://repository.hanyang.ac.kr/handle/20.500.11754/120152
ISSN
0165-9936; 1879-3142
DOI
10.1016/j.trac.2018.07.006
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > CIVIL AND ENVIRONMENTAL ENGINEERING(건설환경공학과) > Articles
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