갑상선 결절의 분자생물학적 진단

Abstract

Fine needle aspiration cytology is gold standard for diagnosis of thyroid nodule. However, it isnot perfect and its results are cytologically indeterminate nodules (Bethesda classification IIIV)in 15-30%, which remains diagnostic challenges. So, the method that provide informationabout cancer risk is necessary to establish management strategy. As results of studies aboutgenetic changes in thyroid cancer, remarkable advances have been achieved in understandingthyroid carcinogenesis, which produced applications of molecular biomarkers and profilingpanels for diagnosis of thyroid nodule. These tests help clinicians make decision regarding theneed for surgery and the surgical extent. In this review, published researches related to moleculardiagnosis of thyroid cancer are reviewed and performance of the diagnostic tests and itsinterpretation were discussed. Korean J Otorhinolaryngol-Head Neck Surg 2018;61(9):445-52