27 0

Full metadata record

DC FieldValueLanguage
dc.contributor.author김진웅-
dc.date.accessioned2019-12-08T19:55:35Z-
dc.date.available2019-12-08T19:55:35Z-
dc.date.issued2018-08-
dc.identifier.citationCLINICAL AND EXPERIMENTAL DERMATOLOGY, v. 43, no. 6, page. 708-712en_US
dc.identifier.issn0307-6938-
dc.identifier.issn1365-2230-
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/abs/10.1111/ced.13557-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/119793-
dc.description.abstractSugar is a well-known cosmetic ingredient for moisturizing skin with minimal side-effects. Several reports have demonstrated an antimelanogenic effect of sugar in melanocytes. We evaluated the whitening efficacy of galacturonic acid (GA), the main component of pectin, as an anti-melanogenic agent. GA significantly suppressed melanin synthesis and secretion in a concentration-dependent manner in -melanocyte stimulating hormone-treated B16 melanoma cells, and inhibited tyrosinase activity and expression at a dose of 10 mmol/L. In a three-dimensional human skin equivalent (MelanoDerm), GA clearly brightened tissue colour. Haematoxylin and eosin and Fontana-Masson (F&M) staining of tissue sections revealed decreased melanin production without skin tissue collapse in the presence of GA. Interestingly, GA dramatically suppressed gene expression of the melanogenic proteins tyrosinase, tyrosinase-related protein (TYRP)-1 and microphthalmia-associated transcription factor, but not TYRP-2. The results support the utility of GA as an effective candidate antimelanogenic agent.en_US
dc.description.sponsorshipThis research was supported and funded by the Application Technology Research Institute of the AmorePacific R&D Center.en_US
dc.language.isoen_USen_US
dc.publisherWILEYen_US
dc.titleDepigmentation efficacy of galacturonic acid through tyrosinase regulation in B16 murine melanoma cells and a three-dimensional human skin equivalenten_US
dc.typeArticleen_US
dc.relation.no6-
dc.relation.volume43-
dc.identifier.doi10.1111/ced.13557-
dc.relation.page708-712-
dc.relation.journalCLINICAL AND EXPERIMENTAL DERMATOLOGY-
dc.contributor.googleauthorLee, C. S.-
dc.contributor.googleauthorBaek, H. S.-
dc.contributor.googleauthorBae, I. -H.-
dc.contributor.googleauthorChoi, S. J.-
dc.contributor.googleauthorKim, Y. J.-
dc.contributor.googleauthorLee, J. H.-
dc.contributor.googleauthorKim, J. W.-
dc.relation.code2018001134-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL[S]-
dc.sector.departmentDEPARTMENT OF BIONANOTECHNOLOGY-
dc.identifier.pidkjwoong-
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE