Bioactive nano-metal-organic frameworks as antimicrobials against Gram-positive and Gram-negative bacteria
- Title
- Bioactive nano-metal-organic frameworks as antimicrobials against Gram-positive and Gram-negative bacteria
- Author
- 김기현
- Keywords
- KLEBSIELLA-PNEUMONIAE; MULTIDRUG-RESISTANCE; DRUG-DELIVERY; ANTIBIOTIC-RESISTANCE; HUMAN-DISEASE; IN-VITRO; NANOPARTICLES; CYTOTOXICITY; ZINC; STRATEGIES
- Issue Date
- 2018-07
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- TOXICOLOGY RESEARCH, v. 7, no. 5, page. 931-941
- Abstract
- More effective antibiotics are needed to overcome the problem of multidrug resistance. The antibacterial efficacies of three Zn-based nano metal-organic frameworks (nMOFs) - IRMOF-3, MOF-5, and Zn-BTC - were explored, both alone and as mixtures with ampicillin and kanamycin. When tested against Escherichia coli, Staphylococcus aureus, Staphylococcus lentus, and Listeria monocytogenes, the nMOF/drug mixtures demonstrated synergistic (IRMOF-3/kanamycin) or additive (other nMOF/drug combinations) effects compared with the nMOFs or antibiotics alone. Zn-Based nMOFs can reduce the burden of the new discovery of antimicrobial pharmaceuticals by increasing the potency of existing antibiotics.
- URI
- https://pubs.rsc.org/en/content/articlelanding/2018/TX/C8TX00087E#!divAbstracthttps://repository.hanyang.ac.kr/handle/20.500.11754/119539
- ISSN
- 2045-452X; 2045-4538
- DOI
- 10.1039/c8tx00087e
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > CIVIL AND ENVIRONMENTAL ENGINEERING(건설환경공학과) > Articles
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