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dc.contributor.author심지원-
dc.date.accessioned2019-12-08T14:33:39Z-
dc.date.available2019-12-08T14:33:39Z-
dc.date.issued2018-07-
dc.identifier.citationNATURE COMMUNICATIONS, v. 9, Article no. 2679en_US
dc.identifier.issn2041-1723-
dc.identifier.urihttps://www.nature.com/articles/s41467-018-04990-3-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/119385-
dc.description.abstractDrosophila hemocytes are akin to mammalian myeloid blood cells that function in stress and innate immune-related responses. A multi-potent progenitor population responds to local signals and to systemic stress by expanding the number of functional blood cells. Here we show mechanisms that demonstrate an integration of environmental carbon dioxide (CO2) and oxygen (O-2) inputs that initiate a cascade of signaling events, involving multiple organs, as a stress response when the levels of these two important respiratory gases fall below a threshold. The CO2 and hypoxia-sensing neurons interact at the synaptic level in the brain sending a systemic signal via the fat body to modulate differentiation of a specific class of immune cells. Our findings establish a link between environmental gas sensation and myeloid cell development in Drosophila. A similar relationship exists in humans, but the underlying mechanisms remain to be established.en_US
dc.description.sponsorshipThe authors thank members of the Shim lab and the Banerjee lab for helpful discussions. The authors acknowledge the Bloomington, VDRC, DGRC, and KDRC Drosophila stock centers and the DSHB hybridoma bank. The authors thank the following individuals for stocks and reagents: C. Evans, H. Agaisse, A. Brand, E. Hafen, B. Lemaitre, T. Kitamoto, Y.N. Jan, G. Rubin, S. Artavanis-Tsakonas, D. Morton and K. Irvine. This work was supported by the Basic Science Research Program through the National Research Foundation (NRF) of Korea funded by the Ministry of Education (NRF-2014S1A2A2028388) and by the Ministry of Science, ICT and Future planning (NRF-2014R1A1A1002685) to J.S.; The UCLA part of this collaboration was supported by a Training Grant in Developmental Hematology (T32 HL086345) to C.M.S.; and the NHLBI grant R01 HL067395 and the Broad Stem Cell Research Center at UCLA to U.B.en_US
dc.language.isoen_USen_US
dc.publisherNATURE PUBLISHING GROUPen_US
dc.subjectSOLUBLE GUANYLYL CYCLASESen_US
dc.subjectBLOOD-CELLSen_US
dc.subjectPROGENITOR MAINTENANCEen_US
dc.subjectRESPIRATORY CONTROLen_US
dc.subjectAVOIDANCE-BEHAVIORen_US
dc.subjectINNATE IMMUNITYen_US
dc.subjectCAROTID-BODYen_US
dc.subjectHEMATOPOIESISen_US
dc.subjectNEURONSen_US
dc.subjectOXYGENen_US
dc.titleSystemic control of immune cell development by integrated carbon dioxide and hypoxia chemosensation in Drosophilaen_US
dc.typeArticleen_US
dc.relation.volume9-
dc.identifier.doi10.1038/s41467-018-04990-3-
dc.relation.page1-10-
dc.relation.journalNATURE COMMUNICATIONS-
dc.contributor.googleauthorCho, Bumsik-
dc.contributor.googleauthorSpratford, Carrie M.-
dc.contributor.googleauthorYoon, Sunggyu-
dc.contributor.googleauthorCha, Nuri-
dc.contributor.googleauthorBanerjee, Utpal-
dc.contributor.googleauthorShim, Jiwon-
dc.relation.code2018003595-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF NATURAL SCIENCES[S]-
dc.sector.departmentDEPARTMENT OF LIFE SCIENCE-
dc.identifier.pidjshim-
dc.identifier.orcidhttp://orcid.org/0000-0003-2409-1130-


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