Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 심지원 | - |
dc.date.accessioned | 2019-12-08T14:33:39Z | - |
dc.date.available | 2019-12-08T14:33:39Z | - |
dc.date.issued | 2018-07 | - |
dc.identifier.citation | NATURE COMMUNICATIONS, v. 9, Article no. 2679 | en_US |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://www.nature.com/articles/s41467-018-04990-3 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/119385 | - |
dc.description.abstract | Drosophila hemocytes are akin to mammalian myeloid blood cells that function in stress and innate immune-related responses. A multi-potent progenitor population responds to local signals and to systemic stress by expanding the number of functional blood cells. Here we show mechanisms that demonstrate an integration of environmental carbon dioxide (CO2) and oxygen (O-2) inputs that initiate a cascade of signaling events, involving multiple organs, as a stress response when the levels of these two important respiratory gases fall below a threshold. The CO2 and hypoxia-sensing neurons interact at the synaptic level in the brain sending a systemic signal via the fat body to modulate differentiation of a specific class of immune cells. Our findings establish a link between environmental gas sensation and myeloid cell development in Drosophila. A similar relationship exists in humans, but the underlying mechanisms remain to be established. | en_US |
dc.description.sponsorship | The authors thank members of the Shim lab and the Banerjee lab for helpful discussions. The authors acknowledge the Bloomington, VDRC, DGRC, and KDRC Drosophila stock centers and the DSHB hybridoma bank. The authors thank the following individuals for stocks and reagents: C. Evans, H. Agaisse, A. Brand, E. Hafen, B. Lemaitre, T. Kitamoto, Y.N. Jan, G. Rubin, S. Artavanis-Tsakonas, D. Morton and K. Irvine. This work was supported by the Basic Science Research Program through the National Research Foundation (NRF) of Korea funded by the Ministry of Education (NRF-2014S1A2A2028388) and by the Ministry of Science, ICT and Future planning (NRF-2014R1A1A1002685) to J.S.; The UCLA part of this collaboration was supported by a Training Grant in Developmental Hematology (T32 HL086345) to C.M.S.; and the NHLBI grant R01 HL067395 and the Broad Stem Cell Research Center at UCLA to U.B. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.subject | SOLUBLE GUANYLYL CYCLASES | en_US |
dc.subject | BLOOD-CELLS | en_US |
dc.subject | PROGENITOR MAINTENANCE | en_US |
dc.subject | RESPIRATORY CONTROL | en_US |
dc.subject | AVOIDANCE-BEHAVIOR | en_US |
dc.subject | INNATE IMMUNITY | en_US |
dc.subject | CAROTID-BODY | en_US |
dc.subject | HEMATOPOIESIS | en_US |
dc.subject | NEURONS | en_US |
dc.subject | OXYGEN | en_US |
dc.title | Systemic control of immune cell development by integrated carbon dioxide and hypoxia chemosensation in Drosophila | en_US |
dc.type | Article | en_US |
dc.relation.volume | 9 | - |
dc.identifier.doi | 10.1038/s41467-018-04990-3 | - |
dc.relation.page | 1-10 | - |
dc.relation.journal | NATURE COMMUNICATIONS | - |
dc.contributor.googleauthor | Cho, Bumsik | - |
dc.contributor.googleauthor | Spratford, Carrie M. | - |
dc.contributor.googleauthor | Yoon, Sunggyu | - |
dc.contributor.googleauthor | Cha, Nuri | - |
dc.contributor.googleauthor | Banerjee, Utpal | - |
dc.contributor.googleauthor | Shim, Jiwon | - |
dc.relation.code | 2018003595 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | jshim | - |
dc.identifier.orcid | http://orcid.org/0000-0003-2409-1130 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.