Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤채옥 | - |
dc.date.accessioned | 2019-12-08T12:20:29Z | - |
dc.date.available | 2019-12-08T12:20:29Z | - |
dc.date.issued | 2018-06 | - |
dc.identifier.citation | BULLETIN OF MATHEMATICAL BIOLOGY, v. 80, no. 6, page. 1615-1629 | en_US |
dc.identifier.issn | 0092-8240 | - |
dc.identifier.issn | 1522-9602 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007%2Fs11538-018-0424-4 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/119208 | - |
dc.description.abstract | Oncolytic virotherapy is an experimental cancer treatment that uses genetically engineered viruses to target and kill cancer cells. One major limitation of this treatment is that virus particles are rapidly cleared by the immune system, preventing them from arriving at the tumour site. To improve virus survival and infectivity Kim et al. (Biomaterials 32(9):2314-2326, 2011) modified virus particles with the polymer polyethylene glycol (PEG) and the monoclonal antibody herceptin. Whilst PEG modification appeared to improve plasma retention and initial infectivity, it also increased the virus particle arrival time. We derive a mathematical model that describes the interaction between tumour cells and an oncolytic virus. We tune our model to represent the experimental data by Kim et al. (2011) and obtain optimised parameters. Our model provides a platform from which predictions may be made about the response of cancer growth to other treatment protocols beyond those in the experiments. Through model simulations, we find that the treatment protocol affects the outcome dramatically. We quantify the effects of dosage strategy as a function of tumour cell replication and tumour carrying capacity on the outcome of oncolytic virotherapy as a treatment. The relative significance of the modification of the virus and the crucial role it plays in optimising treatment efficacy are explored. | en_US |
dc.description.sponsorship | The authors received support through an Australian Postgraduate Award (ALJ) and Australian Research Council Discovery Project DP180101512 (PSK and ACFC). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | SPRINGER | en_US |
dc.subject | Optimisation | en_US |
dc.subject | Mathematical modelling | en_US |
dc.subject | Ordinary differential equations | en_US |
dc.title | Mathematical Modelling of the Interaction Between Cancer Cells and an Oncolytic Virus: Insights into the Effects of Treatment Protocols | en_US |
dc.type | Article | en_US |
dc.relation.no | 6 | - |
dc.relation.volume | 80 | - |
dc.identifier.doi | 10.1007/s11538-018-0424-4 | - |
dc.relation.page | 1615-1629 | - |
dc.relation.journal | BULLETIN OF MATHEMATICAL BIOLOGY | - |
dc.contributor.googleauthor | Jenner, Adrianne L. | - |
dc.contributor.googleauthor | Yun, Chae-Ok | - |
dc.contributor.googleauthor | Kim, Peter S. | - |
dc.contributor.googleauthor | Coster, Adelle C. F. | - |
dc.relation.code | 2018002872 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | chaeok | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.