Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신흥수 | - |
dc.date.accessioned | 2019-12-08T11:49:42Z | - |
dc.date.available | 2019-12-08T11:49:42Z | - |
dc.date.issued | 2018-06 | - |
dc.identifier.citation | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, v. 106, no. 6, page. 1732-1742 | en_US |
dc.identifier.issn | 1549-3296 | - |
dc.identifier.issn | 1552-4965 | - |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.a.36374 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/119188 | - |
dc.description.abstract | Biological responses on biomaterials occur either on their surface or at the interface. Therefore, surface characterization is an essential step in the fabrication of ideal biomaterials for achieving effective control of the interaction between the material surface and the biological environment. Herein, we applied femtosecond laser ablation on electrospun fibrous scaffolds to fabricate various hierarchical patterns with a focus on the alignment of cells. We investigated the simultaneously stimulated response of cardiomyoblasts based on multiple topographical cues, including scales, oriented directions, and spatial arrangements, in the fibrous scaffolds. Our results demonstrated a synergistic effect on cell behaviors of one or more structural arrangements in a homogeneous orientation, whereas antagonistic effects were observed for cells arranged on a surface with heterogeneous directions. Taken together, these results indicate that our hierarchically patterned fibrous scaffolds may be useful tools for understanding the cellular behavior on fibrous scaffolds used to mimic an extracellular matrix-like environment. | en_US |
dc.description.sponsorship | Contract grant sponsor: KIST project; contract grant number: 2E26900Contract grant sponsor: Korea Health Industry Development Institute (KHIDI); contract grant number: HI16C0133 | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | WILEY | en_US |
dc.subject | electrospinning | en_US |
dc.subject | ECM | en_US |
dc.subject | topographical cue | en_US |
dc.subject | cardiomyoblasts | en_US |
dc.title | Effect of spatial arrangement and structure of hierarchically patterned fibrous scaffolds generated by a femtosecond laser on cardiomyoblast behavior | en_US |
dc.type | Article | en_US |
dc.relation.no | 6 | - |
dc.relation.volume | 106 | - |
dc.identifier.doi | 10.1002/jbm.a.36374 | - |
dc.relation.page | 1732-1742 | - |
dc.relation.journal | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | - |
dc.contributor.googleauthor | Jun, Indong | - |
dc.contributor.googleauthor | Kim, Kyeongsoo | - |
dc.contributor.googleauthor | Chung, Yong-Woo | - |
dc.contributor.googleauthor | Shin, Hyeok Jun | - |
dc.contributor.googleauthor | Han, Hyung-Seop | - |
dc.contributor.googleauthor | Edwards, James R. | - |
dc.contributor.googleauthor | Ok, Myoung-Ryul | - |
dc.contributor.googleauthor | Kim, Yu-Chan | - |
dc.contributor.googleauthor | Seok, Hyun-Kwang | - |
dc.contributor.googleauthor | Shin, Heungsoo | - |
dc.relation.code | 2018001592 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | hshin | - |
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