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Effect of spatial arrangement and structure of hierarchically patterned fibrous scaffolds generated by a femtosecond laser on cardiomyoblast behavior

Title
Effect of spatial arrangement and structure of hierarchically patterned fibrous scaffolds generated by a femtosecond laser on cardiomyoblast behavior
Author
신흥수
Keywords
electrospinning; ECM; topographical cue; cardiomyoblasts
Issue Date
2018-06
Publisher
WILEY
Citation
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, v. 106, no. 6, page. 1732-1742
Abstract
Biological responses on biomaterials occur either on their surface or at the interface. Therefore, surface characterization is an essential step in the fabrication of ideal biomaterials for achieving effective control of the interaction between the material surface and the biological environment. Herein, we applied femtosecond laser ablation on electrospun fibrous scaffolds to fabricate various hierarchical patterns with a focus on the alignment of cells. We investigated the simultaneously stimulated response of cardiomyoblasts based on multiple topographical cues, including scales, oriented directions, and spatial arrangements, in the fibrous scaffolds. Our results demonstrated a synergistic effect on cell behaviors of one or more structural arrangements in a homogeneous orientation, whereas antagonistic effects were observed for cells arranged on a surface with heterogeneous directions. Taken together, these results indicate that our hierarchically patterned fibrous scaffolds may be useful tools for understanding the cellular behavior on fibrous scaffolds used to mimic an extracellular matrix-like environment.
URI
https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.a.36374https://repository.hanyang.ac.kr/handle/20.500.11754/119188
ISSN
1549-3296; 1552-4965
DOI
10.1002/jbm.a.36374
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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