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Egr-1 is required for neu/HER2-induced mammary tumors

Title
Egr-1 is required for neu/HER2-induced mammary tumors
Author
신인철
Keywords
Egr-1; Neu; HER2; Mammary tumors
Issue Date
2018-05
Publisher
ELSEVIER SCIENCE INC
Citation
CELLULAR SIGNALLING, v. 45, page. 102-109
Abstract
Egr-1 is known to function mainly as a tumor suppressor through direct regulation of multiple tumor suppressor genes. To determine the role of Egr-1 in breast tumors in vivo, we used mouse models of breast cancer induced by HER2/neu. We compared neu-overexpressing Egr-1 knockout mice (neu/Egr-1 KO) to neu-overexpressing Egr-1 wild type or heterozygote mice (neu/Egr-1 WT or neu/Egr-1 het) with regard to onset of tumor appearance and number of tumors per mouse. In addition, to examine the role of Egr-1 in vitro, we established neu/Egr-1 WT and KO tumor cell lines derived from breast tumors developed in each mouse. Egr-1 deletion delayed tumor development in vivo and decreased the rate of cell growth in vitro. These results suggest that Egr-1 plays an oncogenic role in HER2/neu-driven mammary tumorigenesis.
URI
https://www.sciencedirect.com/science/article/pii/S0898656818300366?via%3Dihubhttp://repository.hanyang.ac.kr/handle/20.500.11754/118771
ISSN
0898-6568; 1873-3913
DOI
10.1016/j.cellsig.2018.02.003
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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