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Serial Changes of Cytokines in Children with Cerebral Palsy Who Received Intravenous Granulocyte-colony Stimulating Factor Followed by Autologous Mobilized Peripheral Blood Mononuclear Cells

Title
Serial Changes of Cytokines in Children with Cerebral Palsy Who Received Intravenous Granulocyte-colony Stimulating Factor Followed by Autologous Mobilized Peripheral Blood Mononuclear Cells
Author
김용주
Keywords
Cytokines; Granulocyte-colony Stimulating Factor (G-CSF); Peripheral Blood Mononuclear Cells; Cerebral Palsy
Issue Date
2018-05
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v. 33, no. 21, Article no. UNSP e102
Abstract
Background: This study was performed to assess serial cytokine changes and their clinical impact in children with cerebral palsy (CP) who received granulocyte-colony stimulating factor (G-CSF) followed by infusion of autologous mobilized peripheral blood mononuclear cells (mPBMC5).Methods: Peripheral blood (PB) samples were collected from 16 CP children at enrollment, and 1 month and 7 months after G-CSF infusion as well as at the end of the study. Cytokine levels were measured by enzyme-linked immunosorbent assays with plasma samples.Results: There were no significant differences in cytokine levels between the mPBMC and placebo groups over 6 months. However, when clinical responders and non-responders were compared, interleukin (IL)-6 (P= 0.050) as well as G-CSF (P= 0.010) were higher in the responders than the non-responders at 1 month, while brain-derived neurotrophic factor (BDNF) (P= 0.030) and insulin-like growth factor (IGF)-1 (P= 0.001) were lower. In addition, BDNF was higher at baseline in the responders than the non-responders (P= 0.030).Conclusion: The changes of G-CSF itself, as well as G-CSF-induced cytokines such as IL-6, may be associated with the clinical improvement of neurologic functions. The G-CSF-induced changes of IL-6, BDNF and IGF-1, and BDNF levels before treatment, could be used as prognostic factors in G-CSF trials in CP children.
URI
https://jkms.org/DOIx.php?id=10.3346/jkms.2018.33.e102http://repository.hanyang.ac.kr/handle/20.500.11754/118598
ISSN
1011-8934; 1598-6357
DOI
10.3346/jkms.2018.33.e102
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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