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Total MRI Small Vessel Disease Burden Correlates with Cognitive Performance, Cortical Atrophy, and Network Measures in a Memory Clinic Population

Title
Total MRI Small Vessel Disease Burden Correlates with Cognitive Performance, Cortical Atrophy, and Network Measures in a Memory Clinic Population
Author
이종민
Keywords
Alzheimer's disease; cerebral small vessel diseases; cognitive dysfunction; magnetic resonance imaging; positronemission tomography; vascular dementia
Issue Date
2018-05
Publisher
IOS PRESS
Citation
JOURNAL OF ALZHEIMERS DISEASE, v. 63, no. 4, page. 1485-1497
Abstract
Background: Recent evidence suggests that combining individual imaging markers of cerebral small vessel disease (SVD) may more accurately reflect its overall burden and better correlate with clinical measures.Objective: We wished to establish the clinical relevance of the total SVD score in a memory clinic population by investigating the association with SVD score and cognitive performance, cortical atrophy, and structural network measures, after adjusting for amyloid-beta burden.Methods: We included 243 patients with amnestic mild cognitive impairment (MCI), Alzheimer's disease dementia, subcortical vascular MCI, or subcortical vascular dementia. All underwent MR and [C-11] PiB- PET scanning and had standardized cognitive testing. Multiple linear regression was used to evaluate the relationships between SVD score and cognition, cortical thickness, and structural network measures. Path analyses were performed to evaluate whether network disruption mediates the effects of SVD score on cortical thickness and cognition.Results: Total SVD score was associated with the performance of frontal (beta-4.31, SE 2.09, p = 0.040) and visuospatial (beta-0.95, SE 0.44, p = 0.032) tasks, and with reduced cortical thickness in widespread brain regions. Total SVD score was negatively correlated with nodal efficiency, as well as changes in brain network organization, with evidence of reduced integration and increasing segregation. Path analyses showed that the associations between SVD score and frontal and visuospatial scores were partially mediated by decreases in their corresponding nodal efficiency and cortical thickness.Conclusion: Total SVD burden has clinical relevance in a memory clinic population and correlates with cognition, and cortical atrophy, as well as structural network disruption.
URI
https://content.iospress.com/articles/journal-of-alzheimers-disease/jad170943http://repository.hanyang.ac.kr/handle/20.500.11754/118545
ISSN
1387-2877; 1875-8908
DOI
10.3233/JAD-170943
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
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