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Interleukin-6-Mediated Induced Pluripotent Stem Cell (iPSC)-Derived Neural Differentiation

Title
Interleukin-6-Mediated Induced Pluripotent Stem Cell (iPSC)-Derived Neural Differentiation
Author
Klaus Heese
Keywords
BDNF; Brain; Interleukin-6; Neuron; Neurotrophin; STAT3
Issue Date
2018-04
Publisher
HUMANA PRESS INC
Citation
MOLECULAR NEUROBIOLOGY, v. 55, no. 4, page. 3513-3522
Abstract
In an aging society with an increasing threat to higher brain cognitive functions due to dementia, it becomes imperative to identify new molecular remedies for supporting adult neurogenesis. Interleukin-6 (IL-6) is a promising cytokine that can support neurogenesis under conditions of neurodegeneration, and neuron replacement is eventually possible due to its agonistic acting soluble receptor sIL-6R. Here, we report that activation of the IL-6-signal transducer and activator of transcription 3 (STAT3) axis is neurogenic and has potential therapeutic applications for the treatment of neurodegenerative diseases such as Parkinson's disease (PD).
URI
https://link.springer.com/article/10.1007%2Fs12035-017-0594-3http://repository.hanyang.ac.kr/handle/20.500.11754/118347
ISSN
0893-7648; 1559-1182
DOI
10.1007/s12035-017-0594-3
Appears in Collections:
GRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING[S](의생명공학전문대학원) > ETC
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