Interleukin-6-Mediated Induced Pluripotent Stem Cell (iPSC)-Derived Neural Differentiation
- Title
- Interleukin-6-Mediated Induced Pluripotent Stem Cell (iPSC)-Derived Neural Differentiation
- Author
- Klaus Heese
- Keywords
- BDNF; Brain; Interleukin-6; Neuron; Neurotrophin; STAT3
- Issue Date
- 2018-04
- Publisher
- HUMANA PRESS INC
- Citation
- MOLECULAR NEUROBIOLOGY, v. 55, no. 4, page. 3513-3522
- Abstract
- In an aging society with an increasing threat to higher brain cognitive functions due to dementia, it becomes imperative to identify new molecular remedies for supporting adult neurogenesis. Interleukin-6 (IL-6) is a promising cytokine that can support neurogenesis under conditions of neurodegeneration, and neuron replacement is eventually possible due to its agonistic acting soluble receptor sIL-6R. Here, we report that activation of the IL-6-signal transducer and activator of transcription 3 (STAT3) axis is neurogenic and has potential therapeutic applications for the treatment of neurodegenerative diseases such as Parkinson's disease (PD).
- URI
- https://link.springer.com/article/10.1007%2Fs12035-017-0594-3https://repository.hanyang.ac.kr/handle/20.500.11754/118347
- ISSN
- 0893-7648; 1559-1182
- DOI
- 10.1007/s12035-017-0594-3
- Appears in Collections:
- GRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING[S](의생명공학전문대학원) > ETC
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