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Reversible Redox Activity by Ion-pH Dually Modulated Duplex Formation of i-Motif DNA with Complementary G-DNA

Title
Reversible Redox Activity by Ion-pH Dually Modulated Duplex Formation of i-Motif DNA with Complementary G-DNA
Author
김선정
Keywords
carbon nanotube; DNA; biosensor
Issue Date
2018-04
Publisher
MDPI
Citation
NANOMATERIALS, v. 8, no. 4, Article no. 226
Abstract
The unique biological features of supramolecular DNA have led to an increasing interest in biomedical applications such as biosensors. We have developed an i-motif and G-rich DNA conjugated single-walled carbon nanotube hybrid materials, which shows reversible conformational switching upon external stimuli such as pH (5 and 8) and presence of ions (Li+ and K+). We observed reversible electrochemical redox activity upon external stimuli in a quick and robust manner. Given the ease and the robustness of this method, we believe that pH- and ion-driven reversible DNA structure transformations will be utilized for future applications for developing novel biosensors.
URI
https://www.mdpi.com/2079-4991/8/4/226http://repository.hanyang.ac.kr/handle/20.500.11754/118330
ISSN
2079-4991
DOI
10.3390/nano8040226
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
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