Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이동윤 | - |
dc.date.accessioned | 2019-12-07T11:43:56Z | - |
dc.date.available | 2019-12-07T11:43:56Z | - |
dc.date.issued | 2018-03 | - |
dc.identifier.citation | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v. 59, page. 28-34 | en_US |
dc.identifier.issn | 1226-086X | - |
dc.identifier.issn | 1876-794X | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S1226086X17305415?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/118067 | - |
dc.description.abstract | Monitoring the intensity of immune reactions is very useful to diagnose the fate of transplanted cells. For directly monitoring immune reactions after pancreatic islet cell transplantation, here graphene oxide (GO) quencher was chemically conjugated with fluorescence dye via Granzyme B (GrB)-specific peptide, so called to GO-based immunosensor. GO-based immunosensor was stably immobilized onto surface of living cells without damage of viability and functionality. The cell-surface camouflaged GO-based immunosensor could detect GrB (> 2 unit/ml) secreted from immune cells, thereby dequenching fluorescence. Collectively, we anticipated that the GO-based immunosensor could be utilized to monitor cell graft rejection after cell therapy in vivo. (C) 2017 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved. | en_US |
dc.description.sponsorship | This study was supported by Basic Science Research Program (NRF-2015R1A2A1A05001832) and partially by the Bio & Medical Technology Development Program (NRF-2015M3A9E2030125) through the National Research Foundation (NRF) funded by the Korean Government (MSIP & MOHW). Also, this study was partially supported by a grant of the Korea Health Technology R&D project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI14C2099). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER SCIENCE INC | en_US |
dc.subject | Graphene oxide | en_US |
dc.subject | Immunosensor | en_US |
dc.subject | Cellular surface camouflage | en_US |
dc.subject | Pancreatic islet | en_US |
dc.subject | Granzyme B | en_US |
dc.title | Cell surface-camouflaged graphene oxide immunosensor for identifying immune reactions | en_US |
dc.type | Article | en_US |
dc.relation.volume | 59 | - |
dc.identifier.doi | 10.1016/j.jiec.2017.10.002 | - |
dc.relation.page | 28-34 | - |
dc.relation.journal | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.contributor.googleauthor | Hwang, Yong Hwa | - |
dc.contributor.googleauthor | Jeon, Eun Ae | - |
dc.contributor.googleauthor | Lee, Dong Yun | - |
dc.relation.code | 2018007973 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | dongyunlee | - |
dc.identifier.orcid | http://orcid.org/0000-0001-7691-0447 | - |
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