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dc.contributor.author이현-
dc.date.accessioned2019-12-06T07:32:46Z-
dc.date.available2019-12-06T07:32:46Z-
dc.date.issued2018-03-
dc.identifier.citationRESPIRATORY RESEARCH, v. 19, Article no. UNSP 36en_US
dc.identifier.issn1465-993X-
dc.identifier.issn1465-9921-
dc.identifier.urihttps://respiratory-research.biomedcentral.com/articles/10.1186/s12931-018-0737-8-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/117991-
dc.description.abstractBackground: The recognition of asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) as a distinct phenotype of COPD or asthma has increased. Although ACO has worse clinical features than non-ACO COPD, limited information is available on long-term outcomes of lung function decline for ACO and non-ACO COPD.Methods: COPD patients with at least 3 years of follow-up were selected from the Korean Obstructive Lung Disease cohort. ACO was defined based on 3 major criteria: 1) airflow limitation in individuals 40 years of age and older, 2) >= 10 pack-years of smoking history, and 3) a history of asthma or bronchodilator response of > 400 mL in forced expiratory volume in 1 s (FEV1) at baseline; and at least 1 minor criterion: 1) history of atopy or allergic rhinitis, 2) two separated bronchodilator responses of >= 12% and 200 mL in FEV1, or 3) peripheral blood eosinophils >= 300 cells/mu L. Lung function decline was compared using a linear mixed effects model for longitudinal data with random intercept and random slope.Results: Among 239 patients, 47 were diagnosed with ACO (19.7%). During the follow-up period, change in smoking status, use of inhaled corticosteroids (ICS) and long-acting beta 2-agonists or ICS and at least 2 exacerbations per year were similar between patients with non-ACO COPD and ACO. Over a median follow-up duration of 5.8 years, patients with non-ACO COPD experienced a faster annual decline in pre-bronchodilator FEV1 than patients with ACO (-29.3 ml/year vs. -13.9 ml/year, P = 0.042), which was persistent after adjustment for confounders affecting lung function decline.Conclusion: Patients with ACO showed favorable longitudinal changes in lung function compared to COPD patients over a median follow-up of 5.8 years.en_US
dc.description.sponsorshipThe KOLD Study was supported by a grant from the Korean Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (HI10C2020 and A102065). This study was supported by Samsung Medical Center Foundation for Medical Research (SMX1151371).en_US
dc.language.isoen_USen_US
dc.publisherBMCen_US
dc.subjectAsthmaen_US
dc.subjectChronic obstructive pulmonary diseaseen_US
dc.subjectLung functionen_US
dc.titleFavorable longitudinal change of lung function in patients with asthma-COPD overlap from a COPD cohorten_US
dc.typeArticleen_US
dc.relation.no36-
dc.relation.volume19-
dc.identifier.doi10.1186/s12931-018-0737-8-
dc.relation.page1-7-
dc.relation.journalRESPIRATORY RESEARCH-
dc.contributor.googleauthorPark, Hye Yun-
dc.contributor.googleauthorLee, Suh-Young-
dc.contributor.googleauthorKang, Danbee-
dc.contributor.googleauthorCho, Juhee-
dc.contributor.googleauthorLee, Hyun-
dc.contributor.googleauthorLim, Seong Yong-
dc.contributor.googleauthorYoon, Ho Il-
dc.contributor.googleauthorRa, Seung Won-
dc.contributor.googleauthorKim, Ki Uk-
dc.contributor.googleauthorOh, Yeon-Mok-
dc.contributor.googleauthorSin, Don D.-
dc.contributor.googleauthorLee, Sang-Do-
dc.contributor.googleauthorPark, Yong Bum-
dc.relation.code2018011477-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidnamuhanayeyo-
dc.identifier.researcherIDG-1336-2018-
dc.identifier.orcidhttp://orcid.org/0000-0002-1269-0913-


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